{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:48:48Z","timestamp":1791107328807,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T00:00:00Z","timestamp":1366588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:p><jats:bold>Background.<\/jats:bold><\/jats:p><jats:p>The frequency of fragrance contact allergy has shown a fluctuating trend over the years.<\/jats:p><jats:p><jats:bold>Objectives.<\/jats:bold><\/jats:p><jats:p>To describe the frequency of positive reactions to the baseline screening agents and fragrance mix (FM) 1 and 2 components, to determine trends of the latter over the years, and to evaluate simultaneous reactions.<\/jats:p><jats:p><jats:bold>Patients and methods<\/jats:bold><\/jats:p><jats:p>This was a cross\u2010sectional study on patch test results of 13 332 patients from January 1990 to December 2011.<\/jats:p><jats:p><jats:bold>Results.<\/jats:bold><\/jats:p><jats:p>Of the total population, 9.6% reacted positively to FM 1, and 6% of 3416 tested with FM 2 reacted positively. Of those tested with both, 30.4% of 349 FM 1\u2010positive patients reacted to FM 2, and 51.7% of 205 FM 2\u2010positive patients reacted to FM 1. Hydroxyisohexyl 3\u2010cyclohexene carboxaldehyde (HICC) and FM 2 were tested simultaneously in 3401 patients: 6 reacted to HICC alone. Nine hundred and forty patients were tested with FM 1 ingredients and 205 with FM 2 ingredients; <jats:italic>Evernia prunastri<\/jats:italic> was the most frequent FM 1 allergen, and HICC was the most frequent FM 2 allergen. Simultaneous reactions were frequently observed.<\/jats:p><jats:p><jats:bold>Conclusions.<\/jats:bold><\/jats:p><jats:p>Fragrance\u2010allergic subjects often show multiple positive reactions, some of which are highly significantly associated. Recently, there has been a decreasing trend in positivity for both <jats:italic>Evernia prunastri<\/jats:italic> and HICC, whereas a slight increase for cinnamyl alcohol has been observed.<\/jats:p>","DOI":"10.1111\/cod.12056","type":"journal-article","created":{"date-parts":[[2013,4,22]],"date-time":"2013-04-22T05:31:55Z","timestamp":1366608715000},"page":"307-313","source":"Crossref","is-referenced-by-count":53,"title":["Results of patch testing with fragrance mix 1, fragrance mix 2, and their ingredients, and <i>Myroxylon pereirae<\/i> and colophonium, over a 21\u2010year 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