{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:17:05Z","timestamp":1772223425679,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T00:00:00Z","timestamp":1374451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Iodopropynyl butylcarbamate (<jats:styled-content style=\"fixed-case\">IPBC<\/jats:styled-content>) is a preservative that may cause contact allergy. The first cases were reported in 1997, and <jats:styled-content style=\"fixed-case\">IPBC<\/jats:styled-content> is currently included in our extended European baseline series in Denmark.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess trends during the period 2000\u20132011 concerning <jats:styled-content style=\"fixed-case\">IPBC<\/jats:styled-content> allergy in Denmark, and to address the question of the significance of concomitant reactions to the thiuram mix.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/materials\/methods<\/jats:title><jats:p>Nine thousand seven hundred and fifty\u2010five (6449 female; 3306 male) patients were patch tested with <jats:styled-content style=\"fixed-case\">IPBC<\/jats:styled-content> and the European baseline series at Gentofte Hospital during 2000\u20132011. The results were registered in an anonymized database, and analyzed with <jats:sc>spss<\/jats:sc>\u2122.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010four cases of <jats:styled-content style=\"fixed-case\">IPBC<\/jats:styled-content> contact allergy were detected. A significant rising trend during 2000\u20132011 was observed, with no significant changes during 2006\u20132011. <jats:styled-content style=\"fixed-case\">MOAHLFA<\/jats:styled-content> index analysis showed that <jats:styled-content style=\"fixed-case\">IPBC<\/jats:styled-content> contact allergy was, in our cohort, significantly more prevalent among male patients, occupational, related to hand eczema, and more frequent among patients over 40 years old. A significant relationship between <jats:styled-content style=\"fixed-case\">IPBC<\/jats:styled-content> and thiuram mix allergy was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">IPBC<\/jats:styled-content> continues to be among the less frequent allergens. A 0.2% concentration in patch testing has contributed to the diagnosis of more sensitizations to this substance. Further studies are needed to clarify the reason for the over\u2010representation of thiuram allergy in patients sensitized to <jats:styled-content style=\"fixed-case\">IPBC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12062","type":"journal-article","created":{"date-parts":[[2013,7,22]],"date-time":"2013-07-22T08:33:55Z","timestamp":1374482035000},"page":"78-85","source":"Crossref","is-referenced-by-count":14,"title":["Contact dermatitis caused by iodopropynyl butylcarbamate in\u00a0Denmark"],"prefix":"10.1111","volume":"69","author":[{"given":"Alejandro","family":"Martin\u2010Gorgojo","sequence":"first","affiliation":[{"name":"Department of Dermatology Clinical University Hospital of Valencia, University of Valencia  Valencia 46010 Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne\u2010Duus","family":"Johansen","sequence":"additional","affiliation":[{"name":"The National Allergy Research Centre Gentofte University Hospital  Hellerup 2900 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00400.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2310\/6620.2010.10053","article-title":"Positive patch\u2010test reactions to iodopropynyl butylcarbamate: retrospective analysis of North American contact dermatitis group data, from 1998 to 2008","volume":"21","author":"Warshaw E M","year":"2010","journal-title":"Dermatitis"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-011-1354-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.11.010"},{"key":"e_1_2_7_6_1","unstructured":"European Commission Cosmetics Ingredients Database.2007. 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