{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T02:13:21Z","timestamp":1769825601782,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T00:00:00Z","timestamp":1371600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Being a contact allergen of general relevance, p<\/jats:italic>\u2010phenylenediamine (PPD<\/jats:styled-content>) is patch tested in the baseline series. However, PPD<\/jats:styled-content> 1% in petrolatum may actively sensitize. Patch testing with PPD<\/jats:styled-content> at 0.35% pet. proved to be safe, as far as active sensitization is concerned.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To determine whether PPD<\/jats:styled-content> 0.3% pet. reliably detects PPD<\/jats:styled-content> sensitization.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patch testing with PPD<\/jats:styled-content> 0.3% pet. and 1% pet. synchronously was performed in consecutive patients in a multicentre study within the Information Network of Departments of Dermatology.<\/jats:p><\/jats:sec>Results<\/jats:title>Altogether, 2042 patients were patch tested. PPD<\/jats:styled-content> 1% pet. yielded 6.0% positive reactions (n\u2009=\u2009123), and PPD<\/jats:styled-content> 0.3% pet. yielded 4.7% (n\u2009=\u200995). The synchronous reproducibility of PPD<\/jats:styled-content> reactions was similar as known from parallel patch tests with identical PPD<\/jats:styled-content> concentrations. The diagnostic properties of PPD<\/jats:styled-content> 0.3% pet. expressed as reaction index and positivity ratio were good. Of the 123 patients reacting to PPD<\/jats:styled-content> 1% pet., 32 (26%) had no positive reaction to PPD<\/jats:styled-content> 0.3% pet. In 22 of these 32 patients (69%), no clinical relevance could be found.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>As patch testing with PPD<\/jats:styled-content> 0.3% pet. is reliable according to our results, we recommend replacing PPD<\/jats:styled-content> 1% pet. in the baseline series with PPD<\/jats:styled-content> 0.3% pet.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12075","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T07:18:28Z","timestamp":1371626308000},"page":"26-31","source":"Crossref","is-referenced-by-count":20,"title":["Monitoring contact sensitization to p<\/i>\u2010phenylenediamine (PPD<\/scp>) by patch testing with PPD<\/scp> 0.3% in petrolatum"],"prefix":"10.1111","volume":"69","author":[{"given":"Johannes","family":"Geier","sequence":"first","affiliation":[{"name":"Information Network of Departments of Dermatology University of G\u00f6ttingen 37075 G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara K.","family":"Ballmer\u2010Weber","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Zurich 8091 Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinrich","family":"Dickel","sequence":"additional","affiliation":[{"name":"Department of Dermatology St Josef Hospital, University Hospitals of the Ruhr\u2010University of Bochum 44791 Bochum Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Frosch","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Witten\/Herdecke and Klinikum Dortmund 44137 Dortmund Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Bircher","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Basel 4031 Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Weisshaar","sequence":"additional","affiliation":[{"name":"Department of Clinical Social Medicine Occupational and Environmental Dermatology, University Hospital of Heidelberg 69115 Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Hillen","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Essen 45122 Essen 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