{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:15:30Z","timestamp":1792088130317,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T00:00:00Z","timestamp":1371600000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>p<\/jats:italic>\u2010Phenylenediamine (<jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content>) is the primary patch test screening agent for hair dye contact allergy, and approximately 100 different hair dye chemicals are allowed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine whether <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> is an optimal screening agent for diagnosing hair dye allergy or whether other clinically important sensitizers exist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two thousand nine hundred and thirty\u2010nine consecutive patients in 12 dermatology clinics were patch tested with five hair dyes available from patch test suppliers. Furthermore, 22 frequently used hair dye ingredients not available from patch test suppliers were tested in subgroups of \u223c\u2009500 patients each.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A positive reaction to <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> was found in 4.5% of patients, and 2.8% reacted to toluene\u20102,5\u2010diamine (<jats:styled-content style=\"fixed-case\">PTD<\/jats:styled-content>), 1.8% to <jats:italic>p<\/jats:italic>\u2010aminophenol, 1% to <jats:italic>m<\/jats:italic>\u2010aminophenol, and 0.1% to resorcinol; all together, 5.3% (n\u2009=\u2009156). Dying hair was the most frequently reported cause of the allergy (55.4%); so\u2010called \u2018temporary henna\u2019 tattoos were the cause in 8.5% of the cases. <jats:italic>p<\/jats:italic>\u2010Methylaminophenol gave a reaction in 20 patients (2.2%), 3 of them with clinical relevance, and no co\u2010reaction with the above five well\u2010known hair dyes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hair dyes are the prime cause of <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> allergy. <jats:styled-content style=\"fixed-case\">PPD<\/jats:styled-content> identifies the majority of positive reactions to <jats:styled-content style=\"fixed-case\">PTD<\/jats:styled-content>, <jats:italic>p<\/jats:italic>\u2010aminophenol and <jats:italic>m<\/jats:italic>\u2010aminophenol, but not all, which justifies additional testing  with hair dye ingredients from the used product.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12077","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T07:18:28Z","timestamp":1371626308000},"page":"32-39","source":"Crossref","is-referenced-by-count":92,"title":["Contact allergy to common ingredients in hair dyes"],"prefix":"10.1111","volume":"69","author":[{"given":"Heidi","family":"S\u00f8sted","sequence":"first","affiliation":[{"name":"Research Centre for Hairdressers and Beauticians, Department of Dermato\u2010Allergology Copenhagen University Hospital Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Rustemeyer","sequence":"additional","affiliation":[{"name":"Department of Dermatology VU University Medical Centre  De Boelelaan 1117 Nl\u20101081 HV Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Gon\u00e7alo","sequence":"additional","affiliation":[{"name":"Clinic of Dermatology University Hospital and Faculty of Medicine, Praceta Mota Pinto  3000\u2010075 Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital Malm\u00f6, Lund University  S\u2010205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Goossens","sequence":"additional","affiliation":[{"name":"Dermatology\/Contact Allergy University Hospital, KU Leuven  Kapucijnenvoer 33 B\u20103000 Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana M.","family":"Gim\u00e9nez\u2010Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar, Universitat Autonoma de Barcelona  08003 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe J.","family":"Le Coz","sequence":"additional","affiliation":[{"name":"Cabinet de Dermatologie Laboratoire de Dermatochimie 4 rue Blaise Pascal  67081 Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"White","sequence":"additional","affiliation":[{"name":"St John's Institute of Dermatology St Thomas' Hospital  SE1 7EH London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas L.","family":"Diepgen","sequence":"additional","affiliation":[{"name":"Department of Social Medicine Occupational and Environmental Dermatology  Thibautstr. 3 69115 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark  DK\u20105000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tove","family":"Agner","sequence":"additional","affiliation":[{"name":"Dermatologisk afd Roskilde Sygehus  K\u00f8gevej 7\u201013 4000 Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Maibach","sequence":"additional","affiliation":[{"name":"Department of Dermatology UCSF, School of Medicine  San Francisco CA 94143\u20100989 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torkil","family":"Menn\u00e9","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology Copenhagen University Hospital Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermato\u2010Allergology Copenhagen University Hospital 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