{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:12:48Z","timestamp":1772223168311,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:00:00Z","timestamp":1372377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cushion bush [<jats:italic>Leucophyta brownii<\/jats:italic> Cass.\u2009=\u2009<jats:italic>Calocephalus brownii<\/jats:italic> (<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ass.) <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>uell.] is an <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ustralian <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ompositae shrub that has been introduced into <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>candinavia as a pot plant. The first case of sensitization occurred in a gardener, and the main allergen was identified as the guaianolide calocephalin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To present the identification of the main allergen, and to assess the prevalence of sensitization to calocephalin in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ompositae\u2010allergic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Calocephalin was isolated from a dichloromethane extract of aerial parts of cushion bush. <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>alocephalin 0.1% ethanol was included in the plant series in <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>alm\u00f6, <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>weden, and <jats:styled-content style=\"fixed-case\">O<\/jats:styled-content>dense, <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>enmark.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nuclear magnetic resonance (<jats:styled-content style=\"fixed-case\">NMR<\/jats:styled-content>) analysis of calocephalin resulted in a revision of its chemical structure to 4\u03b1\u2010acetoxy\u20101\u03b1,2\u03b1\u2010epoxy\u20105\u03b1,10\u03b1H\u2010guai\u201011(13)\u2010en\u201012,8\u03b2\u2010olide. The prevalence of patch test positivity was up to 28% in aimed patch testing. Despite strongly positive patch test reactions, the relevance was unknown in the majority of cases, and only 1 person was occupationally sensitized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Calocephalin is a potent contact allergen, but, as cushion bush is a low\u2010maintenance pot plant, primary sensitization is most likely to occur through occupational exposure. Positive reactions in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ompositae\u2010sensitive persons probably occur because of cross\u2010reactivity, and patients should be warned about contact with cushion bush plants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12096","type":"journal-article","created":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T04:56:43Z","timestamp":1372395403000},"page":"303-310","source":"Crossref","is-referenced-by-count":12,"title":["Contact sensitization to calocephalin, a sesquiterpene lactone of the guaianolide type from cushion bush (<i>Leucophyta brownii<\/i>, Compositae)"],"prefix":"10.1111","volume":"69","author":[{"given":"Evy","family":"Paulsen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark  DK\u20105000 Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars P.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Biotechnology and Environmental Technology University of Southern Denmark  DK\u20105230 Odense M Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Hinds\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Occupational Dermatology Sk\u00e5ne University Hospital  205 02 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark  DK\u20105000 Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,6,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1071\/CH9660143"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.0309cw.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07674.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03827-3_24"},{"key":"e_1_2_6_6_1","first-page":"47","article-title":"The biogenesis and chemistry of sesquiterpene lactones","volume":"38","author":"Fischer N H","year":"1979","journal-title":"Prog Chem Org Nat Prod"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(98)00453-0"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450402.x"},{"key":"e_1_2_6_9_1","first-page":"313","volume-title":"Opportunity, Challenge and Scope of Natural Products in Medicinal Chemistry","author":"Chaturvedi D","year":"2011"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-80331-4_9"},{"key":"e_1_2_6_11_1","volume-title":"Allergiepflanzen\u2010Pflanzenallergene: Handbuch und Atlas der Allergie\u2010induzierenden Wild\u2010 und Kulturpflanzen","author":"Hausen B M","year":"1997"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01822.x"},{"key":"e_1_2_6_13_1","unstructured":"J C Mitchell A Rook 1979 Greengrass Vancouver"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.045001029.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12096","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T20:52:25Z","timestamp":1696366345000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,28]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1111\/cod.12096"],"URL":"https:\/\/doi.org\/10.1111\/cod.12096","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,28]]}}}