{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:21:48Z","timestamp":1791073308409,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:00:00Z","timestamp":1372377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Loss\u2010of\u2010function mutations in the filaggrin gene (\n \n FLG<\/jats:styled-content>\n <\/jats:italic>\n ) are associated with xerosis, atopic dermatitis, and early onset of hand eczema. Irritant exposure is a risk factor for occupational hand eczema, and\n \n FLG<\/jats:styled-content>\n <\/jats:italic>\n mutations increase the risk of occupational irritant contact dermatitis on the hands in hospital cohorts. It is unknown whether\n \n FLG<\/jats:styled-content>\n <\/jats:italic>\n mutations affect the level of irritant exposure.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To evaluate whether exposure to occupational irritants was dependent on\n \n FLG<\/jats:styled-content>\n <\/jats:italic>\n mutations, atopic dermatitis, and age at hand eczema onset.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Randomly chosen\n D<\/jats:styled-content>\n anish adults completed a questionnaire on general health and occupational exposures. Genotyping for\n \n FLG<\/jats:styled-content>\n <\/jats:italic>\n mutations (\n R501X<\/jats:styled-content>\n , 2282del4, and\n R2447X<\/jats:styled-content>\n ) and patch testing were performed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Overall, 38.7% of subjects reported present or previous occupational exposure to irritants. Among individuals who reported hand eczema onset before entering their work life, 50.6% (45\/89) of\n FLG<\/jats:italic>\n non\u2010mutation carriers became exposed to irritants, as compared with 28.6% (4\/14) of heterozygous and 0% (0\/6) of homozygous mutation carriers (\n p<\/jats:italic>\n \u2009=\u20090.006). Avoidance was conspicuous among mutation carriers reporting childhood hand eczema and atopic dermatitis (odds ratio 0.08, 95% confidence interval 0.01\u20130.65).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Carriers of\n \n FLG<\/jats:styled-content>\n <\/jats:italic>\n mutations who have had hand eczema onset in childhood avoid occupational exposure to irritants; the association is most marked with homozygous mutation status combined with atopic dermatitis.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cod.12097","type":"journal-article","created":{"date-parts":[[2013,6,28]],"date-time":"2013-06-28T00:57:20Z","timestamp":1372381040000},"page":"355-362","source":"Crossref","is-referenced-by-count":35,"title":["Carriers of filaggrin gene (\n \n FLG<\/scp>\n <\/i>\n ) mutations avoid professional exposure to irritants in adulthood"],"prefix":"10.1111","volume":"69","author":[{"given":"Josefine","family":"Bandier","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte Hellerup 2900 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine","family":"Ross\u2010Hansen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte Hellerup 2900 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berit C.","family":"Carlsen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte Hellerup 2900 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torkil","family":"Menn\u00e9","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte Hellerup 2900 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Linneberg","sequence":"additional","affiliation":[{"name":"Research Centre for Prevention and Health Copenhagen University Hospital Glostrup Glostrup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen","family":"Stender","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Gentofte Hellerup 2900 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pal B.","family":"Szecsi","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Gentofte Hellerup 2900 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Meldgaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry Copenhagen University Hospital Gentofte Hellerup 2900 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte Hellerup 2900 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte Hellerup 2900 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,6,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.01.053"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01671.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.29"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.153"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700994"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1743"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1767"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700587"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0883"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048678"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08730.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09245.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12035"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12083"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10530.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200203040-00006"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08850.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01831.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09157.x"},{"key":"e_1_2_6_21_1","first-page":"8","article-title":"Risks 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