{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T21:09:11Z","timestamp":1778015351120,"version":"3.51.4"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T00:00:00Z","timestamp":1373500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Occupational skin contact with lipophilic substances is a risk factor for the development of irritant hand dermatitis. Skin protection creams form part of the personal protective equipment, and some are claimed to protect against lipophilic irritants. However, their benefit against solvents is under debate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy of barrier creams claimed to protect against lipophilic irritants in a newly developed repetitive irritation model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010five healthy volunteers were enrolled in a double\u2010blind, randomized study, and six barrier creams were evaluated against irritation induced by two occupationally relevant model solvents, n\u2010octane and cumene. Clinical scoring and bioengineering methods (capacitance and transepidermal water loss measurements) were used to quantify the irritant reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>None of the test products offered protection against n\u2010octane\u2010induced clinical irritation or stratum corneum dehydration. One test product significantly aggravated the skin irritation induced by both irritants, and a second one enhanced dehydration induced by n\u2010octane only.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The lack of efficacy and the aggravation of skin irritation induced by two of six test products stress the need for standardized efficacy testing of occupational skin protection products.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12103","type":"journal-article","created":{"date-parts":[[2013,7,11]],"date-time":"2013-07-11T13:28:39Z","timestamp":1373549319000},"page":"363-371","source":"Crossref","is-referenced-by-count":40,"title":["Protective creams fail to prevent solvent\u2010induced cumulative skin irritation\u2009\u2013\u2009results of a randomized double\u2010blind study"],"prefix":"10.1111","volume":"69","author":[{"given":"Sibylle","family":"Schliemann","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Jena  07743 Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kleesz","sequence":"additional","affiliation":[{"name":"Convenor of the working group \u2018Skin protection\u2019 in the Expert Committee \u2018Personal Protective Equipment\u2019, German Statutory Accident Insurance (DGUV)  53757 Sankt Augustin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Elsner","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Jena  07743 Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00273.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200203040-00006"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00423.x"},{"key":"e_1_2_6_5_1","first-page":"1","article-title":"Occupational skin diseases","volume":"35","author":"Halkier\u2010Sorensen L","year":"1996","journal-title":"Contact Dermatitis"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2007.00409.x"},{"key":"e_1_2_6_7_1","first-page":"65","article-title":"Bovine udder skin (BUS): testing of skin compatibility and skin protection","volume":"23","author":"Pittermann W F","year":"2006","journal-title":"ALTEX"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000099601"},{"key":"e_1_2_6_9_1","unstructured":"FartaschM DiepgenT L DrexlerH ElsnerP FluhrJ W JohnS M KreskenJ Wigger\u2010AlbertiW.Berufliche Hautmittel. 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