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In addition, 431 patients underwent prick testing with common type I allergens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 67 patients showed a heterozygous mutation in the <jats:styled-content style=\"fixed-case\"><jats:italic>FLG<\/jats:italic><\/jats:styled-content> alleles <jats:styled-content style=\"fixed-case\">R501X<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">R2447X<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">S3247X<\/jats:styled-content>, and\/or 2282del4. Sensitization rates for type I allergens from a European prick test series did not show significant differences between <jats:styled-content style=\"fixed-case\"><jats:italic>FLG<\/jats:italic><\/jats:styled-content> loss\u2010of\u2010function mutation carriers and wild\u2010type subjects. For type <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> allergens, significantly more <jats:styled-content style=\"fixed-case\"><jats:italic>FLG<\/jats:italic><\/jats:styled-content> loss\u2010of\u2010function carriers were found to be sensitized to lanolin and <jats:italic>p<\/jats:italic>\u2010tert\u2010butylphenol\u2010formaldehyde resin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Probably a variety of immunological mechanisms other than that resulting from the filaggrin system have an impact on allergic sensitization to a greater degree. Larger cohorts may be necessary to increase the statistical power of the findings presented regarding type <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> sensitization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12109","type":"journal-article","created":{"date-parts":[[2013,7,15]],"date-time":"2013-07-15T09:19:43Z","timestamp":1373879983000},"page":"27-34","source":"Crossref","is-referenced-by-count":12,"title":["No remarkable differences in rates of sensitization to common type <scp>I<\/scp> and <scp>IV<\/scp> allergens between <i><scp>FLG<\/scp><\/i> loss\u2010of\u2010function mutation carriers and wild\u2010type subjects"],"prefix":"10.1111","volume":"70","author":[{"given":"Lilla","family":"Landeck","sequence":"first","affiliation":[{"name":"Department of Dermatology, Environmental Medicine and Health Theory University of Osnabr\u00fcck 49090 Osnabr\u00fcck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maaike","family":"Visser","sequence":"additional","affiliation":[{"name":"Coronel Institute of Occupational Health, Academic Medical Centre University of Amsterdam 1100 DE Amsterdam The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Skudlik","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Environmental Medicine and Health Theory University of Osnabr\u00fcck 49090 Osnabr\u00fcck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Brans","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Environmental Medicine and Health Theory University of Osnabr\u00fcck 49090 Osnabr\u00fcck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanja","family":"Kezic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swen Malte","family":"John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,7,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011040"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12083"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12035"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.06.046"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.358"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(96)00119-9"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02171.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1256476"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03827-3_24"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01232.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0383"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.07.026"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.05.004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700630"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.038"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09708.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.01.026"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.02.014"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2433"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700739"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.01.013"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.10-RAI-0270"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.08.030"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.03.036"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2010.11.001"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1001\/archderm.1976.01630340009002","article-title":"Immunodeficiencies in severe atopic dermatitis. 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