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The objective of the review is to systematically retrieve, evaluate and classify evidence on contact allergy to fragrances, in order to arrive at recommendations for targeting of primary and secondary prevention. Besides published evidence on contact allergy in humans, animal data (local lymph node assay), annual use volumes and structure\u2013activity relationships (\n                    <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>\n                    s) were considered for an algorithmic categorization of substances as contact allergens. A total of 54 individual chemicals and 28 natural extracts (essential oils) can be categorized as established contact allergens in humans, including all 26 substances previously identified as contact allergens (SCCNFP\/0017\/98). Twelve of the 54 individual chemicals are considered to be of special concern, owing to the high absolute number of reported cases of contact allergy (&gt; 100). Additionally, 18 single substances and one natural mixture are categorized as established contact allergens in animals.\n                    <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>\n                    s, combined with limited human evidence, contributed to the categorization of a further 26 substances as likely contact allergens. In conclusion, the presence of 127 single fragrance substances and natural mixtures should, owing to their skin sensitizing properties, be disclosed, for example on the label. As an additional preventive measure, the maximum use concentration of 11 substances of special concern should be limited to 100 ppm. The substance hydroxyisohexyl 3\u2010cyclohexene carboxaldehyde and the two ingredients chloroatranol and atranol in the natural extracts\n                    <jats:italic>Evernia prunastri<\/jats:italic>\n                    and\n                    <jats:italic>Evernia furfuracea<\/jats:italic>\n                    should not be present in cosmetic products.\n                  <\/jats:p>","DOI":"10.1111\/cod.12117","type":"journal-article","created":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T04:15:17Z","timestamp":1374898517000},"page":"196-230","source":"Crossref","is-referenced-by-count":75,"title":["Categorization of fragrance contact allergens for prioritization of preventive measures: clinical and experimental data and consideration of structure\u2013activity relationships"],"prefix":"10.1111","volume":"69","author":[{"given":"Wolfgang","family":"Uter","sequence":"first","affiliation":[{"name":"Department of Medical Informatics, Biometry and Epidemiology University of Erlangen\/N\u00fcrnberg 91054 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology, National Allergy Research Centre Gentofte Hospital, University of Copenhagen 2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"B\u00f6rje","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Molecular Biology University of Gothenburg 41137 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Therese","family":"Karlberg","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Molecular Biology University of Gothenburg 41137 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Lid\u00e9n","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet 17177 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh","family":"Rastogi","sequence":"additional","affiliation":[{"name":"Member of the SCCS Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Roberts","sequence":"additional","affiliation":[{"name":"Liverpool John Moores University Liverpool, Merseyside L3 5UZ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Allergy, St John's Institute of Dermatology St Thomas' Hospital London SE1 7EH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,27]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"SCCNFP.The Scientific Committee on Cosmetic Products and Non\u2010Food Products intended for Consumers: Opinion concerning Fragrance allergy in consumers. 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