{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:21:48Z","timestamp":1791073308083,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T00:00:00Z","timestamp":1374883200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The preservative methylisothiazolinone (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>) has become an important allergen, with a dramatic increase in sensitization prevalence being seen over the last few years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine risk factors associated with <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> sensitization, in order to identify targets of prevention aimed at curtailing the present epidemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>On the basis of contact allergy surveillance data collected by the Information Network of Departments of Dermatology (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ivkd.org\">www.ivkd.org<\/jats:ext-link>), 2009\u20132012, in the course of 28\u2009922 patch tests with <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, 500\u2009ppm in water, included in a series of cosmetic preservatives, logistic regression analysis was employed to quantify the risk associated with a number of putative risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> sensitization increased from 1.94% in 2009 to 6.02% in 2012, the increase being mainly driven by female patients aged \u2265\u200940\u2009years, patients with face dermatitis, and the use of cosmetics. Adjusted multifactorial analysis additionally identified several occupations (e.g. painters and beauticians) and ano\u2010genital dermatitis as risk factors for <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> sensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present use concentrations of <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, both cosmetic and industrial, are too high; (self\u2010)regulatory action is urgently needed. <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> should be added to the baseline series.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12123","type":"journal-article","created":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T08:15:09Z","timestamp":1374912909000},"page":"231-238","source":"Crossref","is-referenced-by-count":113,"title":["Risk factors associated with methylisothiazolinone contact sensitization"],"prefix":"10.1111","volume":"69","author":[{"given":"Wolfgang","family":"Uter","sequence":"first","affiliation":[{"name":"Department of Medical Informatics, Biometry and Epidemiology University of Erlangen\/N\u00fcrnberg 91054 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Geier","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology University of G\u00f6ttingen 37075 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Carl Gustav Carus Technical University of Dresden 01307 Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Schnuch","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology University of G\u00f6ttingen 37075 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,7,27]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"The Scientific Committee on Cosmetic Products and Non\u2010Food Products Intended for Consumers Opinion Concerning Methylisothiazolinone (SCCNFP\/0625\/02 and SCCNFP\/0805\/04)","author":"SCCNFP","year":"2004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10523.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02157.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e31827edc73"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02834.x"},{"key":"e_1_2_7_7_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2012"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00406.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.46.s4.29_102.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12069"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06511.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01754.x"},{"key":"e_1_2_7_13_1","volume-title":"The SCCS's Notes of Guidance for the Testing of Cosmetic Ingredients and their Safety Evaluation, 7. 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