{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:17Z","timestamp":1787014037107,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T00:00:00Z","timestamp":1375401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The evidence on the safety of topical preparations containing botanical extracts is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess (i) the use of botanically derived compounds in a large population, (ii) the incidence of cutaneous side\u2010effects, and (iii) the diagnostic usefulness of patch testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A questionnaire was used in 2661 patients to assess both the prevalence and type of topical botanical preparations used, and the occurrence of adverse skin reactions. Patients declaring adverse reactions were patch tested with (i) the\n                      <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                      talian (\n                      <jats:styled-content style=\"fixed-case\">SIDAPA<\/jats:styled-content>\n                      ) baseline series, (ii) an additional botanical series, and (iii) the patients' own products.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the patients, 1274 (48%) reported the use of topical botanical products; 139 patients (11%) commented on adverse cutaneous reactions; 75 (54%) showed positive reactions with the\n                      <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>\n                      talian baseline series. Among the 122 patients tested with the botanical series, 19 (16%) showed positive reactions, in many cases with concomitant relevant positivity to at least one allergen of the Italian series connected with cosmetics. The commonest botanically derived allergens were propolis,\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      ompositae extracts, and\n                      <jats:italic>Melaleuca alternifolia<\/jats:italic>\n                      (tea tree) oil.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Contact allergy is a possible adverse effect of natural products. Baseline series supplemented with the commonest botanical allergens may be adequate for detecting most of the cases of contact allergy to natural topical products.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.12124","type":"journal-article","created":{"date-parts":[[2013,8,2]],"date-time":"2013-08-02T10:16:15Z","timestamp":1375438575000},"page":"90-97","source":"Crossref","is-referenced-by-count":56,"title":["Topical botanically derived products: use, skin reactions, and usefulness of patch tests. A multicentre\n                    <scp>I<\/scp>\n                    talian study"],"prefix":"10.1111","volume":"70","author":[{"given":"Monica","family":"Corazza","sequence":"first","affiliation":[{"name":"Department of Medical Sciences, Section of Dermatology University of Ferrara, I\u201044121 Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Borghi","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Section of Dermatology University of Ferrara, I\u201044121 Ferrara Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosella","family":"Gallo","sequence":"additional","affiliation":[{"name":"Section of Dermatology\u2009\u2013\u2009DISSAL University of Genoa, I\u201016132 Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donatella","family":"Schena","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Dermatology and Venereology University of Verone, I\u201037126  Verone Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pigatto","sequence":"additional","affiliation":[{"name":"Department of Biosciences for Health, Ospedale Galeazzi University of Milan, I\u201020161 Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Michela","family":"Lauriola","sequence":"additional","affiliation":[{"name":"Policlinico san Marco Dermatology Department, I\u201024040 Zingonia\u2010Osio Sotto (BG) Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Guarneri","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Dermatology University of Messina, I\u201098124 Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Stingeni","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Specialities and Public Health Unit of 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