{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:50:15Z","timestamp":1792291815096,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,12]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>The use of cosmetics exposes consumers to mixtures of ingredients, many of which are contact allergens. Fragrances in particular are mostly used in combination; combinations of fragrances have been shown to enhance sensitization and elicitation.<\/jats:p><\/jats:sec>Objective<\/jats:title>To examine the pattern of co\u2010exposure to fragrances in different categories of cosmetics, addressing the 26 fragrances that need to be identified on the label according to the C<\/jats:styled-content>osmetics D<\/jats:styled-content>irective 76\/768\/EEC<\/jats:styled-content> amended by 2003\/15\/EC<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A survey of products marketed in G<\/jats:styled-content>ermany, conducted in 2006\u20132009 by the C<\/jats:styled-content>hemical and V<\/jats:styled-content>eterinary I<\/jats:styled-content>nvestigation O<\/jats:styled-content>ffice in K<\/jats:styled-content>arlsruhe, identified 4991 products with information on the presence of fragrances. The products were categorized according to A<\/jats:styled-content>nnex I<\/jats:styled-content> to the C<\/jats:styled-content>osmetics D<\/jats:styled-content>irective. The occurrence and co\u2010occurrence of fragrances were analysed in tabular form and as social network diagrams.<\/jats:p><\/jats:sec>Results<\/jats:title>The median number of fragrances in products varied greatly between categories, ranging up to nine in perfumes. Limonene and linalool were the most commonly identified fragrances, often used together, but also with other fragrances. Thirty per cent of all products were not declared to contain any fragrances.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>For the first time, the pattern of co\u2010exposure to fragrance ingredients in important categories of cosmetic products has been described. The observations illustrate and quantify the \u2018cocktail\u2019 of fragrance allergens that may facilitate sensitization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12125","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T16:26:54Z","timestamp":1381249614000},"page":"335-341","source":"Crossref","is-referenced-by-count":76,"title":["Coupled exposure to ingredients of cosmetic products: I<\/scp>. Fragrances"],"prefix":"10.1111","volume":"69","author":[{"given":"Wolfgang","family":"Uter","sequence":"first","affiliation":[{"name":"Department of Medical Informatics, Biometry and Epidemiology Friedrich\u2010Alexander\u2010University Erlangen\/N\u00fcrnberg D\u201091054 Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerem","family":"Yazar","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet SE\u2010171 77 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva\u2010Maria","family":"Kratz","sequence":"additional","affiliation":[{"name":"Chemical and Veterinary Investigation Office (CVUA Karlsruhe) D\u201076187 Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Mildau","sequence":"additional","affiliation":[{"name":"Chemical and Veterinary Investigation Office (CVUA Karlsruhe) D\u201076187 Karlsruhe Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Lid\u00e9n","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institutet SE\u2010171 77 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,9,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2005.05040"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2009.09038"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08018.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01939.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01945.x"},{"key":"e_1_2_6_7_1","first-page":"35","article-title":"Risikoorientierte Probenplanung (RIOP) bei der U\u00fcberwachung kosmetischer Mittel","volume":"104","author":"Walther C","year":"2008","journal-title":"Dtsch Lebensmitt Rundsch"},{"key":"e_1_2_6_8_1","first-page":"26","article-title":"Directive 2003\/15\/EC of the EP of 27 February 2003 amending Council directive 76\/768\/EEC","volume":"66","author":"Anonymous","year":"2003","journal-title":"Off J"},{"key":"e_1_2_6_9_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2012"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01979.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01828.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01601.x"},{"key":"e_1_2_6_13_1","volume-title":"Scientific Committee on Consumer Safety (SCCS) Opinion on Fragrance Allergens in Cosmetic Products, 26 June 2012","author":"SCCS","year":"2012"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12117"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00939.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01657.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.08.014"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02064.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02363.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12125","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12125","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:23:04Z","timestamp":1696321384000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,19]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/cod.12125"],"URL":"https:\/\/doi.org\/10.1111\/cod.12125","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,19]]}}}