{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:20:31Z","timestamp":1790382031588,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T00:00:00Z","timestamp":1390435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fragrance ingredients can cause contact allergy, which may affect quality of life (<jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content>). However, few studies have investigated this topic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> life among subjects with a fragrance allergy as compared with other eczema patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2013control survey was sent to subjects with a positive patch test reaction to a fragrance ingredient\/marker (n\u2009=\u2009550) and to a control group (n\u2009=\u20091100). It contained questions on eczema and the newly developed fragrance <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> index. Participants had been consecutively patch tested at <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>entofte <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital (2000\u20132010). The response rate was 65.7%. Information on patch test data was retrieved from the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ational <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ontact <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ermatitis <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>atabase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An increase in impairment of <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> was observed in women with fragrance allergy as compared with the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.042), which was not found among men. Several factors played a significant role in impairment of <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> in women: (i) number of fragrance allergies, (ii) severity of the patch test reaction, (iii) age combined with recent diagnosis; and (iv) allergy to specific fragrance ingredients\/markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fragrance\u2010allergic subjects are just as affected in their <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> as other eczema patients. However, women, and in particular recently diagnosed young women, seem to be more impaired in their <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> than other eczema patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12128","type":"journal-article","created":{"date-parts":[[2014,1,23]],"date-time":"2014-01-23T06:22:52Z","timestamp":1390458172000},"page":"81-89","source":"Crossref","is-referenced-by-count":26,"title":["Fragrance allergy and quality of life\u2009\u2013\u2009a case\u2013control study"],"prefix":"10.1111","volume":"70","author":[{"given":"Maria V.","family":"Heisterberg","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte, University of Copenhagen  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torkil","family":"Menn\u00e9","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte, University of Copenhagen  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte, University of Copenhagen  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02070.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01626.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01170.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22604.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01362.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04692.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04043.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01776.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01292.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2648.1999.00891.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0143034391121010"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05883.x"},{"key":"e_1_2_6_15_1","first-page":"287","article-title":"Terminology of contact dermatitis","volume":"50","author":"Wilkinson D S","year":"1970","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01737.x"},{"key":"e_1_2_6_17_1","unstructured":"The European Commission.Consolidated version of Cosmetics Directive 76\/768\/EEC of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products Cosmetic Restriction III\/I 79 2005. 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