{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:45:48Z","timestamp":1790520348841,"version":"4.1.0"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,9,19]],"date-time":"2013-09-19T00:00:00Z","timestamp":1379548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"name":"Foundation Institute GAK (Hilversum, The Netherlands)"},{"name":"Wellcome Trust Bioresources Grant","award":["090066\/B\/09\/Z"],"award-info":[{"award-number":["090066\/B\/09\/Z"]}]},{"name":"Wellcome Trust Strategic Award","award":["098439\/Z\/12\/Z"],"award-info":[{"award-number":["098439\/Z\/12\/Z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background\/objectives<\/jats:title>\n                    <jats:p>\n                      Environmental exposure and personal susceptibility both contribute to the development of hand eczema. In this study, we investigated the effect of loss\u2010of\u2010function mutations in the filaggrin gene (\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content>\n                      <\/jats:italic>\n                      ), atopic dermatitis and wet work exposure on the development of hand eczema in apprentice nurses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Dutch apprentice nurses were genotyped for the four most common\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content>\n                      <\/jats:italic>\n                      mutations; atopic dermatitis and hand eczema history were assessed by questionnaire. Exposure and hand eczema during traineeships were assessed with diary cards.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The prevalence of hand eczema during traineeships was higher among subjects with a history of hand eczema reported at inclusion. Hand washing during traineeships and at home increased the risk of hand eczema. After adjustment for the effects of exposure and\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content>\n                      <\/jats:italic>\n                      mutations, an odds ratio of 2.5 (90% confidence interval 1.7\u20133.7) was found for a history of atopic dermatitis. In this study, an increased risk of hand eczema conferred by\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content>\n                      <\/jats:italic>\n                      mutations could not be shown, but subjects with concomitant\n                      <jats:italic>\n                        <jats:styled-content style=\"fixed-case\">FLG<\/jats:styled-content>\n                      <\/jats:italic>\n                      mutations and atopic dermatitis showed the highest risk of hand eczema during traineeships.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A history of atopic dermatitis, a history of hand eczema and wet work exposure were the most important factors increasing the risk of hand eczema during traineeships.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.12139","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T11:16:10Z","timestamp":1381230970000},"page":"139-150","source":"Crossref","is-referenced-by-count":73,"title":["Filaggrin loss\u2010of\u2010function mutations and atopic dermatitis as risk factors for hand eczema in apprentice nurses: part\n                    <scp>II<\/scp>\n                    of a prospective cohort study"],"prefix":"10.1111","volume":"70","author":[{"given":"Maaike J.","family":"Visser","sequence":"first","affiliation":[{"name":"Coronel Institute of Occupational Health, Academic Medical Centre University of Amsterdam Amsterdam Meibergdreef 15, 1105 AZ The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten M.","family":"Verberk","sequence":"additional","affiliation":[{"name":"Coronel Institute of Occupational Health, Academic Medical Centre University of Amsterdam Amsterdam Meibergdreef 15, 1105 AZ The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda E.","family":"Campbell","sequence":"additional","affiliation":[{"name":"Centre for Dermatology and Genetic Medicine, Colleges of Life Sciences and Medicine, Dentistry &amp; Nursing, Medical Sciences Institute University of Dundee Dundee Dow Street, DD1 5EH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. H. Irwin","family":"McLean","sequence":"additional","affiliation":[{"name":"Centre for Dermatology and Genetic Medicine, Colleges of Life Sciences and Medicine, Dentistry &amp; Nursing, Medical Sciences Institute University of Dundee Dundee Dow Street, DD1 5EH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florentine","family":"Calkoen","sequence":"additional","affiliation":[{"name":"Coronel Institute of Occupational Health, Academic Medical Centre University of Amsterdam Amsterdam Meibergdreef 15, 1105 AZ The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan G.","family":"Bakker","sequence":"additional","affiliation":[{"name":"Netherlands Centre for Occupational Diseases, Academic Medical Centre University of Amsterdam Amsterdam Meibergdreef 15, 1105 AZ The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J. 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