{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T21:09:27Z","timestamp":1778015367543,"version":"3.51.4"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T00:00:00Z","timestamp":1381881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Frequent skin cleaning fulfils the definition of occupational \u2018wet work\u2019. Standardized methods are required to assess the irritation potential of workplace cleansers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To develop a standardized procedure for testing the irritation potential of occupational skin cleansers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this single\u2010blind, single\u2010centre trial in 25 healthy volunteers, the irritation potential of five generic reference cleansers was tested by three\u2010times\u2010daily washing with an automated skin cleaning device for 4\u2009days, and quantification of cumulative skin barrier damage was performed by visual scoring, chromametry, transepidermal water loss <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content>, and corneometry. For two cleansers, reproducibility of the irritancy assessment was assessed. Furthermore, the irritation induced by four commercial workplace skin cleansers was studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Whereas no significant changes were observed for any of the tested cleansers by either visual scoring or chromametry, significant increases in <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> and significant decreases in stratum corneum hydration were found for all cleansers. Cleansers differed significantly in their irritation potential. On retesting of two cleansers, the first results were confirmed. Among the four commercial cleansers, one that was claimed to be mild was found to be disproportionally irritant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presented model for testing cleansing preparations allows a highly controlled, practically relevant and reproducible irritancy assessment of occupational skin cleansers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12140","type":"journal-article","created":{"date-parts":[[2013,10,16]],"date-time":"2013-10-16T14:12:59Z","timestamp":1381932779000},"page":"151-157","source":"Crossref","is-referenced-by-count":20,"title":["Development of a standardized testing procedure for assessing the irritation potential of occupational skin cleansers"],"prefix":"10.1111","volume":"70","author":[{"given":"Peter","family":"Elsner","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Jena Erfurter Strasse 35 D\u201007743 Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Seyfarth","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Jena Erfurter Strasse 35 D\u201007743 Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitar","family":"Antonov","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Jena Erfurter Strasse 35 D\u201007743 Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swen Malte","family":"John","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Environmental Medicine, Health Theory University of Osnabrueck 49069 Osnabrueck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Diepgen","sequence":"additional","affiliation":[{"name":"Department of Social Medicine, Occupational and Environmental Dermatology University of Heidelberg 69115 Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibylle","family":"Schliemann","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Jena Erfurter Strasse 35 D\u201007743 Jena Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,16]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"Ausschuss f\u00fcr Gefahrstoffe (AGS).Technische Regel f\u00fcr Gefahrstoffe 401 2008."},{"key":"e_1_2_6_3_1","unstructured":"IKW FCIO SKW and BVH.Group data sheets for skin products (for occupational use). 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