{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:32:44Z","timestamp":1771014764213,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,10,9]],"date-time":"2013-10-09T00:00:00Z","timestamp":1381276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The currently used patch test concentration of formaldehyde (1.0% aqua; 0.30\u2009mg\/cm<jats:sup>2<\/jats:sup>) has been shown to fail to detect \u02dc\u200950% of contact allergies to formaldehyde.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To justify the inclusion of formaldehyde 2.0% aqua (0.60\u2009mg\/cm<jats:sup>2<\/jats:sup>) in the European baseline patch test series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A survey of the reported frequencies of contact allergy to formaldehyde found with formaldehyde 2.0% aqua as compared with 1.0% aqua was performed. Studies that describe a standardized patch test technique for obtaining a correct dose per unit area were included. Experimental provocation tests in patients with contact allergy to formaldehyde detected only with 2.0% aqua were also surveyed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a multicentre study performed in 12 dermatology clinics among 3591 individuals, 3.4% reacted to 2.0%, and 1.8% reacted to 1.0% (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). A randomized double\u2010blind repeated open application test performed in individuals reacting only to 2.0% but not to 1.0% showed that 9 of 17 formaldehyde\u2010allergic individuals reacted to a moisturizer that contained formaldehyde (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is recommended that formaldehyde 2.0% aqua (0.60\u2009mg\/cm<jats:sup>2<\/jats:sup>) should replace formaldehyde 1.0% in the European baseline series from 2014. With the Finn Chamber<jats:sup>\u00ae<\/jats:sup> technique, a standardized amount of 15\u2009\u00b5l of the solution obtained by using a micropipette should be used.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12148","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:10:37Z","timestamp":1381543837000},"page":"372-374","source":"Crossref","is-referenced-by-count":32,"title":["Recommendation to include formaldehyde 2.0% aqua in the <scp>E<\/scp>uropean baseline patch test series"],"prefix":"10.1111","volume":"69","author":[{"given":"Ann","family":"Pont\u00e9n","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University Malm\u00f6 SE\u201020502 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Goossens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital, K.U. Leuven Leuven, B\u20103000 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University Malm\u00f6 SE\u201020502 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06154.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12150"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01953.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10253.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01181.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0925"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01797.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02169.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10151.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12148","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:23:10Z","timestamp":1696321390000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,9]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["10.1111\/cod.12148"],"URL":"https:\/\/doi.org\/10.1111\/cod.12148","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,9]]}}}