{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:19:11Z","timestamp":1792088351011,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T00:00:00Z","timestamp":1381536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007036","name":"Danish Environmental Protection Agency","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007036","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,11]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>The prevalence of contact allergy to the isothiazolinone preservative methylchloroisothiazolinone (MCI<\/jats:styled-content>) in combination with methylisothiazolinone (MI<\/jats:styled-content>) and MI<\/jats:styled-content> alone has increased in the last couple of years.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To investigate the prevalence of contact allergy to MI<\/jats:styled-content>, MCI<\/jats:styled-content>\/MI<\/jats:styled-content> and benzisothiazolinone (BIT<\/jats:styled-content>) among patch tested patients at Gentofte Hospital, as well as the use of MI<\/jats:styled-content> in cosmetic products.<\/jats:p><\/jats:sec>Methods<\/jats:title>Patients patch tested with either MI<\/jats:styled-content>, MCI<\/jats:styled-content>\/MI<\/jats:styled-content> or BIT<\/jats:styled-content> from 2010 to 2012 were included in the study. The MOAHLFA<\/jats:styled-content> index was registered in all patch tested patients, and relevant exposures were determined in patients with an isothiazolinone allergy. In a market survey, the ingredient labels of cosmetic products were investigated for MI<\/jats:styled-content> content.<\/jats:p><\/jats:sec>Results<\/jats:title>The prevalence of MI<\/jats:styled-content> and MCI<\/jats:styled-content>\/MI<\/jats:styled-content> contact allergy increased significantly from 2010 to 2012: from 2.0% to 3.7% for MI<\/jats:styled-content> (n\u2009=\u20092766), and from 1.0% to 2.4% for MCI<\/jats:styled-content>\/MI<\/jats:styled-content> (n\u2009=\u20092802). MI<\/jats:styled-content>\u2010allergic patients had occupational, hand and face dermatitis significantly more often, and were aged >\u200940\u2009years. Cosmetics were the most common substances causing relevant exposure found in both MCI<\/jats:styled-content>\/MI<\/jats:styled-content>\u2010allergic and MI<\/jats:styled-content>\u2010allergic patients. MI<\/jats:styled-content> was found in 3.3% of cosmetics on the Danish retail market.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The increase in MI<\/jats:styled-content> contact allergy is alarming, and urgent action is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12149","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T13:16:05Z","timestamp":1444742165000},"page":"271-275","source":"Crossref","is-referenced-by-count":101,"title":["Methylisothiazolinone contact allergy\u2009\u2013\u2009a growing epidemic"],"prefix":"10.1111","volume":"69","author":[{"given":"Michael D.","family":"Lundov","sequence":"first","affiliation":[{"name":"National Allergy Research Centre, Department of Dermato\u2010Allergology Copenhagen University Hospital Gentofte Gentofte DK\u20102820 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten S.","family":"Opstrup","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermato\u2010Allergology Copenhagen University Hospital Gentofte Gentofte DK\u20102820 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermato\u2010Allergology Copenhagen University Hospital Gentofte Gentofte DK\u20102820 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,10,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02157.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12064"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12098"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02093.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01924.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12050"},{"issue":"2","key":"e_1_2_5_8_1","first-page":"30","article-title":"Methylisothiazolinone\u2009\u2013\u2009direct and airborne exposure from paint","volume":"66","author":"Lundov M D","year":"2012","journal-title":"Contact Dermatitis"},{"key":"e_1_2_5_9_1","unstructured":"European Commision (2007)Council Directive 76\/768\/EEC of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products Council Directive 76\/768\/EEC of 27 July 1976 on the approximation of the laws of the Member States relating to cosmetic products."},{"key":"e_1_2_5_10_1","unstructured":"SCCS.Opinion on benzisothiazolinone 2012July 26."},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01939.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10523.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01828.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01774.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01754.x"},{"key":"e_1_2_5_16_1","first-page":"287","article-title":"Terminology of contact dermatitis","volume":"50","author":"Wilkinson D S","year":"1970","journal-title":"Acta Derm 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