{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:19:11Z","timestamp":1792088351017,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T00:00:00Z","timestamp":1381536000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Methylisothiazolinone (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>) is used as a preservative in occupational and household products, and cosmetics. It is a part of the preparation of methylchloroisothiazolinone (<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>)\/<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, which is patch tested in water in the European baseline series. However, this preparation fails to detect a significant percentage of allergic contact reactions to <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether a separate test preparation with <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> should be included in the European baseline series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In consecutively tested dermatitis patients, the contact allergy rate for <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> varies between 0.6% and 6%, with a marked increase in recent years. The contact allergy rate for <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> alone, not detected with <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, varies between 0% and 1.6%. Most cases are relevant, as shown by repeated open application test studies, and are mainly related to exposure from cosmetic products.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Owing to the increase in contact allergy to <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> not detected with <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, it is recommended that <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> in water at 2000\u2009ppm be included in the European baseline series. With the Finn Chamber<jats:sup>\u00ae<\/jats:sup> (diameter, 8\u2009mm) technique, a volume of 15\u2009\u00b5l should be applied, giving a dose of 60\u2009\u00b5g\/cm<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12150","type":"journal-article","created":{"date-parts":[[2015,10,13]],"date-time":"2015-10-13T21:48:46Z","timestamp":1444772926000},"page":"263-270","source":"Crossref","is-referenced-by-count":90,"title":["Recommendation to include methylisothiazolinone in the <scp>E<\/scp>uropean baseline patch test series\u2009\u2013\u2009on behalf of the <scp>E<\/scp>uropean <scp>S<\/scp>ociety of <scp>C<\/scp>ontact Dermatitis and the <scp>E<\/scp>uropean <scp>E<\/scp>nvironmental and <scp>C<\/scp>ontact <scp>D<\/scp>ermatitis <scp>R<\/scp>esearch <scp>G<\/scp>roup"],"prefix":"10.1111","volume":"69","author":[{"given":"Magnus","family":"Bruze","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University 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