{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:12:40Z","timestamp":1772223160161,"version":"3.50.1"},"reference-count":4,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T00:00:00Z","timestamp":1382572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Allergic reactions to spectacle frames are not unusual. A patient had a reproducible strong allergic patch test reaction to scrapings from the plastic material, and negative patch test results with available spectacle frame chemicals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify the culprit allergen in this patient's spectacle frame.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>An extract from the temple arms was analysed by gas chromatography mass spectrometry (<jats:styled-content style=\"fixed-case\">GC\u2010MS<\/jats:styled-content>), and a major low molecular weight compound was detected. This compound was isolated by semi\u2010preparative high\u2010performance liquid chromatography and identified by <jats:styled-content style=\"fixed-case\">GC\u2010MS<\/jats:styled-content> and nuclear magnetic resonance spectroscopy. The purified compound was diluted in ethanol, and a dilution series was prepared for patch testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Triethylene glycol bis(2\u2010ethylhexanoate) was identified as the major compound in the extract. Patch testing of the patient proved that triethylene glycol bis(2\u2010ethylhexanoate) was the causative allergen in the spectacle frame. Ten consecutive eczema patients tested as controls were negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Triethylene glycol bis(2\u2010ethylhexanoate) is a new, hitherto unreported contact allergen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12152","type":"journal-article","created":{"date-parts":[[2013,10,24]],"date-time":"2013-10-24T11:19:43Z","timestamp":1382613583000},"page":"112-116","source":"Crossref","is-referenced-by-count":19,"title":["Triethylene glycol bis(2\u2010ethylhexanoate)\u2009\u2013\u2009a new contact allergen identified in a spectacle frame"],"prefix":"10.1111","volume":"70","author":[{"given":"Klaus E.","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark  Sdr. Boulevard 29, DK\u20105000 Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malene E.","family":"Vestergaard","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark  Sdr. Boulevard 29, DK\u20105000 Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars P.","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Biotechnology and Environmental Technology University of Southern Denmark, Campusvej 55 DK\u20105230 Odense M Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00791.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05802.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2340\/0001555576136140","article-title":"The Allergen Bank a source of extra contact allergens for the dermatologist in practice","volume":"76","author":"Andersen K E","year":"1996","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01781.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12152","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T23:50:52Z","timestamp":1696290652000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,24]]},"references-count":4,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/cod.12152"],"URL":"https:\/\/doi.org\/10.1111\/cod.12152","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,24]]}}}