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The effect on <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> has not yet been investigated, and no disease\u2010specific <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> instrument for fragrance allergy exists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To develop and validate a disease\u2010specific instrument to investigate <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> among fragrance\u2010allergic subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A fragrance <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> instrument (<jats:styled-content style=\"fixed-case\">FQL<\/jats:styled-content> index) was developed on the basis of narratives from 68 fragrance\u2010allergic subjects, and consisted of 13 items. It was tested in a postal survey among 1650 participants patch tested at <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>entofte <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>niversity <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ospital (2000\u20132010). The survey included other <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> instruments [Dermatology Life Quality Index (<jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>) and Short Form 36 (<jats:styled-content style=\"fixed-case\">SF36<\/jats:styled-content>) version 2] and questions on eczema severity (response rate of 66%). A retest was conducted after 3\u20136\u2009months (response rate of 72.5%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">FQL<\/jats:styled-content> index showed a significant and strong correlation with the <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content> (<jats:italic>r<\/jats:italic><jats:sub>S<\/jats:sub>\u2009=\u20090.70), and disease severity, but a weak correlation with <jats:styled-content style=\"fixed-case\">SF36<\/jats:styled-content> [mental component summary score, <jats:italic>r<\/jats:italic><jats:sub>S<\/jats:sub>\u2009=\u2009\u2212\u20090.22; physical component summary score, <jats:italic>r<\/jats:italic><jats:sub>S<\/jats:sub>\u2009=\u2009\u2212\u20090.31]. Good reliability and responsiveness to changes in disease severity were seen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">FQL<\/jats:styled-content> index is a good instrument with which to investigate <jats:styled-content style=\"fixed-case\">QoL<\/jats:styled-content> in subjects with fragrance allergy. Good correlations with the <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content> and self\u2010estimated disease severity were seen, and it showed good reliability, reproducibility and ability to distinguish changes in disease severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12153","type":"journal-article","created":{"date-parts":[[2013,12,11]],"date-time":"2013-12-11T06:40:49Z","timestamp":1386744049000},"page":"69-80","source":"Crossref","is-referenced-by-count":14,"title":["Fragrance allergy and quality of life\u2009\u2013\u2009development and validation of a disease\u2010specific quality of life instrument"],"prefix":"10.1111","volume":"70","author":[{"given":"Maria V.","family":"Heisterberg","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte, University of Copenhagen, Niels Andersens Vej 65 2900 Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torkil","family":"Menn\u00e9","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte, University of Copenhagen, Niels Andersens Vej 65 2900 Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte, University of Copenhagen, Niels Andersens Vej 65 2900 Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,12,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01737.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01287.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb02435.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01626.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.07050.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06494.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09099.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.22604.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02071.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322007000300006"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04692.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01630.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.440204.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(88)90058-9"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200607030-00005"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2005.01941.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00833.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70210-X"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0143034391121010"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01167.x"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.d01-1225.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155500750012153"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00108-5"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00083-3"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00107-3"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00092-4"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00091-2"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00111-5"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00435438"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.86.2.420"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05883.x"},{"key":"e_1_2_6_33_1","first-page":"287","article-title":"Terminology of contact dermatitis","volume":"50","author":"Wilkinson D S","year":"1970","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_34_1","unstructured":"The European Commission. 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