{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:21:23Z","timestamp":1789399283447,"version":"build-2803163510"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,2,21]],"date-time":"2014-02-21T00:00:00Z","timestamp":1392940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Chemotechnique Diagnostics, Vellinge, Sweden,"},{"name":"Swedish Asthma and Allergy Association, Stockholm, Sweden,"},{"name":"Welander-Finsen Foundation, Stockholm, Sweden,"},{"name":"Health & Medical Care Committee of the Region V\u00e4stra G\u00f6taland (ALF), Sweden."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Linalool is a commonly used fragrance terpene that forms potent sensitizers upon oxidation. In a recent multicentre study, we found that 7% of 2900 patients showed positive patch test reactions to oxidized linalool at 6.0%. No elicitation studies have been performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To identify threshold concentrations for elicitation of allergic contact dermatitis caused by oxidized linalool in allergic individuals with repeated exposures.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Repeated open application tests were performed in 6 participants previously diagnosed with contact allergy to oxidized linalool. Creams containing 3.0%, 1.0% and 0.30% oxidized linalool (corresponding to 0.56%, 0.19% and 0.056% linalool hydroperoxides, respectively) and \u2018fine fragrance\u2019 containing 1.0%, 0.30% and 0.10% oxidized linalool (corresponding to 0.19%, 0.056% and 0.019% linalool hydroperoxides, respectively) were used twice daily for up to 3\u2009weeks. Patch testing with a dilution series of oxidized linalool was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five of 6 participants reacted to the cream containing 3% oxidized linalool. With 1% oxidized linalool, a reaction was seen in 3 (cream) and 4 (fine fragrance) participants, respectively. With 0.3% oxidized linalool, 2 (cream) and 1 (fine fragrance) participants reacted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Repeated exposure to low concentrations of oxidized linalool can elicit allergic contact dermatitis in previously sensitized individuals.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.12163","type":"journal-article","created":{"date-parts":[[2014,2,22]],"date-time":"2014-02-22T03:52:19Z","timestamp":1393041139000},"page":"129-138","source":"Crossref","is-referenced-by-count":39,"title":["Air\u2010oxidized linalool elicits eczema in allergic patients\u2009\u2013\u2009a repeated open application test study"],"prefix":"10.1111","volume":"70","author":[{"given":"Ylva","family":"Andersch Bj\u00f6rkman","sequence":"first","affiliation":[{"name":"Department of Dermatology Sahlgrenska Academy at University of Gothenburg 41345 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Hagvall","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sahlgrenska Academy at University of Gothenburg 41345 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Siwmark","sequence":"additional","affiliation":[{"name":"Chemotechnique Diagnostics 23539 Vellinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Niklasson","sequence":"additional","affiliation":[{"name":"Chemotechnique Diagnostics 23539 Vellinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Therese","family":"Karlberg","sequence":"additional","affiliation":[{"name":"Dermatochemistry and Skin Allergy, Department of Chemistry and Molecular Biology University of Gothenburg 40530 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Br\u00e5red Christensson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sahlgrenska Academy at University of Gothenburg 41345 Gothenburg Sweden"},{"name":"Dermatochemistry and Skin Allergy, Department of Chemistry and Molecular Biology University of Gothenburg 40530 Gothenburg 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