{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:21:59Z","timestamp":1772223719583,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T00:00:00Z","timestamp":1397520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Negative patch test results with fragrance allergy markers in the <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean baseline series do not always predict a negative reaction to individual fragrance substances.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the frequencies of positive test reactions to the 26 fragrance substances for which labelling is mandatory in the <jats:styled-content style=\"fixed-case\">EU<\/jats:styled-content>, and how effectively reactions to fragrance markers in the baseline series predict positive reactions to the fragrance substances that are labelled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The records of 1951 eczema patients, routinely tested with the labelled fragrance substances and with an extended <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean baseline series in 2011 and 2012, were retrospectively reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and eighty\u2010one (14.4%) (71.2% females) reacted to one or more allergens from the labelled\u2010fragrance substance series and\/or a fragrance marker from the <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean baseline series. The allergens that were positive with the greatest frequencies were cinnamyl alcohol (48; 2.46%), <jats:italic>Evernia furfuracea<\/jats:italic> (44; 2.26%), and isoeugenol (40; 2.05%). Of the 203 patients who reacted to any of the 26 fragrances in the labelled\u2010fragrance substance series, only 117 (57.6%) also reacted to a fragrance marker in the baseline series. One hundred and seven (52.7%) reacted to either fragrance mix <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> or fragrance mix <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, 28 (13.8%) reacted to <jats:italic>Myroxylon pereirae<\/jats:italic>, and 13 (6.4%) reacted to hydroxyisohexyl 3\u2010cyclohexene carboxaldehyde.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings confirm that the standard fragrance markers fail to identify patients with contact allergies to the 26 fragrances.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12171","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T06:43:40Z","timestamp":1397544220000},"page":"276-281","source":"Crossref","is-referenced-by-count":66,"title":["Baseline series fragrance markers fail to predict contact allergy"],"prefix":"10.1111","volume":"70","author":[{"given":"Jack","family":"Mann","sequence":"first","affiliation":[{"name":"Friends Dermatology Centre Kent and Canterbury Hospital  CT13NG Canterbury UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"McFadden","sequence":"additional","affiliation":[{"name":"St John's Institute of Dermatology St Thomas' Hospital  SE1 7EH London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan M. L.","family":"White","sequence":"additional","affiliation":[{"name":"St John's Institute of Dermatology St Thomas' Hospital  SE1 7EH London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian R.","family":"White","sequence":"additional","affiliation":[{"name":"St John's Institute of Dermatology St Thomas' Hospital  SE1 7EH London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piu","family":"Banerjee","sequence":"additional","affiliation":[{"name":"St John's Institute of Dermatology St Thomas' Hospital  SE1 7EH London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050725"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470107.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.09022.x"},{"key":"e_1_2_5_5_1","volume-title":"Fragrance Allergy in Consumers. A Review of the Problem","author":"EU Scientific Committee on Cosmetic and Non\u2010Food Products Intended for Consumers"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02037.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04345.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01962.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1993.tb03373.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1985.tb01059.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06129.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2003.0264.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e31824a6104"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01739.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00565.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01648.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.01062.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01442.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2003.00135.x"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00939.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00605.x"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00270.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.124817"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01657.x"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02103.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470104.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.12797.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00031.x"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01498.x"},{"key":"e_1_2_5_30_1","unstructured":"ESCD fragrance working party web page statement. Available at:http:\/\/www.escd.org\/working_parties\/fragrance(last accessed 21 August 2013)."},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01088.x"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12056"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01287.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12171","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T05:09:29Z","timestamp":1696568969000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,4,15]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,5]]}},"alternative-id":["10.1111\/cod.12171"],"URL":"https:\/\/doi.org\/10.1111\/cod.12171","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,4,15]]}}}