{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T00:50:37Z","timestamp":1771635037736,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T00:00:00Z","timestamp":1394496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Patch test positivity to parthenolide was observed less often than expected in strongly suspected cases of parthenium dermatitis after <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hemotechnique <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>iagnostics (<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>weden) replaced parthenium extract with parthenolide (0.5% pet.) by itself while marketing its Indian baseline series for patch testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The study was performed to find whether parthenolide detects parthenium contact sensitivity more effectively than parthenium extract in patients clinically presenting with classic parthenium dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>One hundred consecutive patients with suspected parthenium dermatitis were patch tested prospectively with the Indian baseline series, parthenium extract (1% aq.) and parthenolide (0.5% pet.) between July 2011 and April 2012.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only 37 of 100 patients with suspected parthenium dermatitis (male\/female ratio of 20:17) reacted to parthenium extract (32 patients), parthenolide (17 patients), or both (12 patients). Reactions to parthenium extract were generally stronger than reactions to parthenolide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patch testing with parthenolide (0.5% pet.) detects fewer cases of suspected parthenium dermatitis than patch testing with parthenium extract (1% aq.).<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12194","type":"journal-article","created":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T11:52:25Z","timestamp":1394538745000},"page":"340-343","source":"Crossref","is-referenced-by-count":15,"title":["Parthenium dermatitis: is parthenolide an effective choice for patch testing?"],"prefix":"10.1111","volume":"70","author":[{"given":"Vikram K.","family":"Mahajan","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy Dr R. P. Govt. Medical College Kangra (Tanda) 176001 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy Dr R. P. Govt. Medical College Kangra (Tanda) 176001 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrinal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy Dr R. P. Govt. Medical College Kangra (Tanda) 176001 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pushpinder S.","family":"Chauhan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy Dr R. P. Govt. Medical College Kangra (Tanda) 176001 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karaninder S.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprosy Dr R. 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