{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T15:21:21Z","timestamp":1789399281357,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T00:00:00Z","timestamp":1393372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The fragrance terpene <jats:styled-content style=\"fixed-case\"><jats:italic>R<\/jats:italic><\/jats:styled-content>\u2010limonene is a very weak sensitizer, but forms allergenic oxidation products upon contact with air. The primary oxidation products of oxidized limonene, the hydroperoxides, have an important impact on the sensitizing potency of the oxidation mixture. One analogue, limonene\u20101\u2010hydroperoxide, was experimentally shown to be a significantly more potent sensitizer than limonene\u20102\u2010hydroperoxide in the local lymph node assay with non\u2010pooled lymph nodes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the pattern of reactivity among consecutive dermatitis patients to two structurally closely related limonene hydroperoxides, limonene\u20101\u2010hydroperoxide and limonene\u20102\u2010hydroperoxide.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Limonene\u20101\u2010hydroperoxide, limonene\u20102\u2010hydroperoxide, at 0.5% in petrolatum, and oxidized limonene 3.0% pet. were tested in 763 consecutive dermatitis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the tested materials, limonene\u20101\u2010hydroperoxide gave most reactions, with 2.4% of the patients showing positive patch test reactions. Limonene\u20102\u2010hydroperoxide and oxidized <jats:italic>R<\/jats:italic>\u2010limonene gave 1.7% and 1.2% positive patch test reactions, respectively. Concomitant positive patch test reactions to other fragrance markers in the baseline series were frequently noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results are in accordance with the experimental studies, as limonene\u20101\u2010hydroperoxide gave more positive patch test reactions in the tested patients than limonene\u20102\u2010hydroperoxide. Furthermore, the results support the specificity of the allergenic activity of the limonene hydroperoxide analogues and the importance of oxidized limonene as a cause of contact allergy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12195","type":"journal-article","created":{"date-parts":[[2014,2,26]],"date-time":"2014-02-26T09:55:05Z","timestamp":1393408505000},"page":"291-299","source":"Crossref","is-referenced-by-count":35,"title":["Limonene hydroperoxide analogues show specific patch test reactions"],"prefix":"10.1111","volume":"70","author":[{"given":"Johanna","family":"Br\u00e5red Christensson","sequence":"first","affiliation":[{"name":"Dermatochemistry and Skin Allergy, Department of Chemistry and Molecular Biology University of Gothenburg SE\u2010405 30 Gothenburg Sweden"},{"name":"Department of Dermatology Sahlgrenska Academy at University of Gothenburg 405 30 Gothenburg 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