{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:26:32Z","timestamp":1789878392861,"version":"4.0.1"},"reference-count":38,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T00:00:00Z","timestamp":1395878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Citronellol is a frequently used fragrance compound in consumer products. It is present in fragrance mix <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, which is used for screening of contact allergy to fragrances. Because of its chemical structure, citronellol could be susceptible to autoxidation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the behaviour of citronellol with that of the structurally similar compounds linalool and geraniol, in terms of ability to autoxidize, the products formed, and the sensitization potencies of these.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Citronellol was exposed to air, and autoxidation was followed by gas chromatography\u2013mass spectrometry (<jats:styled-content style=\"fixed-case\">GC\u2013MS<\/jats:styled-content>) analysis after derivatization of thermolabile compounds. The sensitizing potencies of the oxidation mixture and its major oxidation compounds were examined with the local lymph node assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The concentration of citronellol decreased while the sensitization potency increased in air\u2010exposed samples over time, with hydroperoxides being identified as the major oxidation products and main skin sensitizers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present study shows the impact of the absence of the 2,3\u2010double bond in the citronellol structure on the oxidation pathways for formation of oxidation products. The study also shows the usefulness of our new <jats:styled-content style=\"fixed-case\">GC\u2013MS<\/jats:styled-content> method for quantification of the citronellol oxidation products, especially the hydroperoxides. The investigated citronellol hydroperoxides could be important allergens, owing to the high concentrations detected and frequent exposure to citronellol in the population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12234","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T07:04:40Z","timestamp":1395903880000},"page":"329-339","source":"Crossref","is-referenced-by-count":31,"title":["Characterization of skin sensitizers from autoxidized citronellol\u2009\u2013\u2009impact of the terpene structure on the autoxidation process"],"prefix":"10.1111","volume":"70","author":[{"given":"Johanna","family":"Rudb\u00e4ck","sequence":"first","affiliation":[{"name":"Department of Chemistry and Molecular Biology Dermatochemistry and Skin Allergy, University of Gothenburg  412 96 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Hagvall","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Molecular Biology Dermatochemistry and Skin Allergy, University of Gothenburg  412 96 Gothenburg Sweden"},{"name":"Department of Dermatology Sahlgrenska Academy, University of Gothenburg  405 30 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"B\u00f6rje","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Molecular Biology Dermatochemistry and Skin Allergy, University of Gothenburg  412 96 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrika","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry Stockholm University  106 91 Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Therese","family":"Karlberg","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Molecular Biology Dermatochemistry and Skin Allergy, University of Gothenburg  412 96 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-74165-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08018.x"},{"key":"e_1_2_7_4_1","first-page":"S1","article-title":"A toxicologic and dermatologic assessment of cyclic and non\u2010cyclic terpene alcohols when used as fragrance ingredients","volume":"46","author":"Belsito D","year":"2008","journal-title":"Food Chem Toxicol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05633.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450406.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00563.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.2340\/0001555572456460","article-title":"Allergic contact sensitization in an unselected Danish population. 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