{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:21:52Z","timestamp":1791073312358,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T00:00:00Z","timestamp":1400716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Danish Working Environment Research Fund","award":["21-2009-09"],"award-info":[{"award-number":["21-2009-09"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In recent years, a steep increase in the frequency of occupational contact allergy to isothiazolinones has been reported from several <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the extent and occurrence of isothiazolinones in different types of product at <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>anish workplaces.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven different isothiazolinones were identified in the <jats:styled-content style=\"fixed-case\"><jats:italic>D<\/jats:italic><\/jats:styled-content><jats:italic>ictionary of<\/jats:italic> <jats:styled-content style=\"fixed-case\"><jats:italic>C<\/jats:italic><\/jats:styled-content><jats:italic>ontact<\/jats:italic> <jats:styled-content style=\"fixed-case\"><jats:italic>A<\/jats:italic><\/jats:styled-content><jats:italic>llergens:<\/jats:italic> <jats:styled-content style=\"fixed-case\"><jats:italic>C<\/jats:italic><\/jats:styled-content><jats:italic>hemical<\/jats:italic> <jats:styled-content style=\"fixed-case\"><jats:italic>S<\/jats:italic><\/jats:styled-content><jats:italic>tructures,<\/jats:italic> <jats:styled-content style=\"fixed-case\"><jats:italic>S<\/jats:italic><\/jats:styled-content><jats:italic>ources, and<\/jats:italic> <jats:styled-content style=\"fixed-case\"><jats:italic>R<\/jats:italic><\/jats:styled-content><jats:italic>eferences<\/jats:italic> from <jats:styled-content style=\"fixed-case\"><jats:italic>K<\/jats:italic><\/jats:styled-content><jats:italic>anerva's<\/jats:italic> <jats:styled-content style=\"fixed-case\"><jats:italic>O<\/jats:italic><\/jats:styled-content><jats:italic>ccupational<\/jats:italic> <jats:styled-content style=\"fixed-case\"><jats:italic>D<\/jats:italic><\/jats:styled-content><jats:italic>ermatitis<\/jats:italic>. By use of the chemical names and <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hemical <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>bstracts <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ervice numbers for these chemicals, information on products registered in the <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>anish <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>roduct <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>egister Database (<jats:styled-content style=\"fixed-case\">PROBAS<\/jats:styled-content>) was obtained.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All seven isothiazolinones were registered in <jats:styled-content style=\"fixed-case\">PROBAS<\/jats:styled-content>. The top three isothiazolinones registered were: benzisothiazolinone (<jats:styled-content style=\"fixed-case\">BIT<\/jats:styled-content>), registered in 985 products, methylisothiazolinone (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>), registered in 884 products, and methylchloroisothiazolinone (MCI)\/MI, registered in 611 products. The concentration ranges were 0.01\u2009ppm to 45% for <jats:styled-content style=\"fixed-case\">BIT<\/jats:styled-content>, 0.01\u2009ppm to 10% for <jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, and 0.01\u2009ppm to 14.1% for <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>. The most common product type was \u2018paint and varnish\u2019; five of the seven isothiazolinones were registered in this type of product.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Isothiazolinones are present in multiple products registered for use at workplaces, and may occur in high concentrations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12235","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T07:38:49Z","timestamp":1400744329000},"page":"65-74","source":"Crossref","is-referenced-by-count":75,"title":["Isothiazolinones in commercial products at <scp>D<\/scp>anish workplaces"],"prefix":"10.1111","volume":"71","author":[{"given":"Ulrik Fischer","family":"Friis","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torkil","family":"Menn\u00e9","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte  2900 Hellerup Denmark"},{"name":"Department of Dermato\u2010Allergology Copenhagen University Hospital Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u2010Ann","family":"Flyvholm","sequence":"additional","affiliation":[{"name":"The National Research Centre for the Working Environment  2100 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Peter Ellekilde","family":"Bonde","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine Copenhagen University Hospital Bispebjerg  2400 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Pierre","family":"Lepoittevin","sequence":"additional","affiliation":[{"name":"Laboratoire de Dermatochimie University of Strasbourg  67081 Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe J.","family":"Le Coz","sequence":"additional","affiliation":[{"name":"Cabinet de Dermatologie, Laboratoire de Dermatochimie  67081 Strasbourg France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne Duus","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte  2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.01058.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06013.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00629.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2009.08.016"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1969.42"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02004_3.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02004_4.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-199X(98)90007-0"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12167"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02004_2.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12081"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1983.tb04473.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01033.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1993.tb03359.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02117.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12068"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1994.tb00707.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12149"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e8221"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12123"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02075.x"},{"key":"e_1_2_6_23_1","volume-title":"Opinion on Benzisothiazolinone","author":"Scientific Committee on Consumer Safety","year":"2012"},{"key":"e_1_2_6_24_1","unstructured":"The European Parliament and the Council of the European Union.Regulation (EC) No. 1223\/2009 of the European Parliament and on the Council of 30 November 2009 on cosmetic products 30 November2009. Available at:http:\/\/eur\u2010lex.europa.eu\/LexUriServ\/LexUriServ.do?uri=OJ:L:2009:342:0059:0209:EN:PDF(last accessed 2 January 2014)."},{"key":"e_1_2_6_25_1","unstructured":"ECHA.Intentions\u2009\u2013\u2009Substances identified for 2013 registration 27 May2013. Available at:http:\/\/echa.europa.eu\/documents\/10162\/13632\/intentions_2013_en.pdf(last accessed 2 January 2014)."},{"key":"e_1_2_6_26_1","unstructured":"ECHA.Regulation on classification labelling and packaging of substances and mixtures amending and repealing Directives 67\/548\/EEC and 1999\/45\/EC and amending Regulation (EC) No. 1907\/2006 the European Parliament and the Council of the European Union 29 October2010. Available at:http:\/\/eur\u2010lex.europa.eu\/LexUriServ\/LexUriServ.do?uri=OJ:L:2008:353:0001:1355:EN:PDF(last accessed 2 January 2014)."},{"key":"e_1_2_6_27_1","unstructured":"The Commission of the European Communities.Commission regulation\u2009\u2013\u2009on the second phase of the 10\u2010year work programme referred to in Article 16(2) of Directive 98\/8\/EC of the European Parliament and of the Council concerning the placing of biocidal products on the market 4 December2007."},{"key":"e_1_2_6_28_1","unstructured":"ECHA.Biocides: non\u2010inclusion decisions 8 December2013. Available at:https:\/\/circabc.europa.eu\/d\/a\/workspace\/SpacesStore\/491962c1\u20108f3e\u20104adb\u20109e0c\u2010cf1a782895d9\/Consolidated%20list%20of%20non\u2010inclusion%20decisions.pdf(last accessed 2 January 2014)."},{"key":"e_1_2_6_29_1","unstructured":"ECHA.List of pre\u2010registered substances 8 December2013. Available at:http:\/\/apps.echa.europa.eu\/preregistered\/attachments\/prs_complete_20090327.csv(last accessed 2 January 2014)."},{"key":"e_1_2_6_30_1","unstructured":"Scientific Committee on Consumer Safety.Opinion on the mixture of 5\u2010chloro\u20102\u2010methylisothiazolin\u20103(2H)\u2010one and 2\u2010methylisothiazolin\u20103(2H)\u2010one Colipa no. P56. 8 December2009. Available at:http:\/\/ec.europa.eu\/health\/scientific_committees\/consumer_safety\/docs\/sccs_o_009.pdf(last accessed 2 January 2014)."},{"key":"e_1_2_6_31_1","unstructured":"ECHA.Registry of current Harmonised Classification and Labelling intentions\u2009\u2013\u2009Methylisothiazolinone: Methylchloroisothiazolinone (1:3) 9 March2012. Available at:http:\/\/echa.europa.eu\/registry\u2010current\u2010classification\u2010and\u2010labelling\u2010intentions\/\u2010\/substance\/1301\/search\/+\/del\/20\/col\/NOTIFICATIONDATEROI_C\/type\/desc\/pre\/2\/view(last accessed 2 January 2014)."},{"key":"e_1_2_6_32_1","unstructured":"The Scientific Committee on Cosmetic Products and Non\u2010Food Products Intended for Consumers.2004.Opinion on methylisothiazolinone Colipa no. P94. 23 April 2004. Available at:http:\/\/ec.europa.eu\/health\/ph_risk\/committees\/sccp\/documents\/out270_en.pdf(last accessed 2 January 2014)."},{"key":"e_1_2_6_33_1","unstructured":"ECHA.Registry of current Harmonised Classification and Labelling intentions\u2009\u2013\u2009Methylisothiazolinone 23 November2013. Available at:http:\/\/echa.europa.eu\/registry\u2010current\u2010classification\u2010and\u2010labelling\u2010intentions\/\u2010\/substance\/2816\/search\/+\/term(last accessed 2 January 2014)."},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-02035-3_199"},{"key":"e_1_2_6_35_1","unstructured":"Danish Working Environment Authority.Substances and materials that must be notified to the Product Registry 0000. Available at:http:\/\/arbejdstilsynet.dk\/en\/engelsk\/produktregistret\/produkter\u2010der\u2010skal\u2010anmeldes.aspx(last accessed 17 December 2013)."},{"key":"e_1_2_6_36_1","unstructured":"Substances in Products in the Nordic Countries. Substances in products in the Nordic Countries Use Categories Nordic (UCN) 12 September2007."},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01924.x"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00225.x"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02012.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb00839.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05656.x"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00850.x"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12054"},{"key":"e_1_2_6_44_1","unstructured":"LundovM D KolarikB BossiR GunnarsenL JohansenJ.Emission of isothiazolinones from water\u2010based paint 2013(in preparation)."},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01278.x"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02093.x"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02016.x"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12050"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05687.x"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00268.x"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00416.x"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01438.x"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0b013e31802c9e79"},{"key":"e_1_2_6_54_1","first-page":"224","article-title":"Sensitization to methylchloroisothiazolinone\u2013methylisothiazolinone after a burn caused by massive accidental occupational exposure","volume":"102","author":"Monsalvez V","year":"2011","journal-title":"Actas Dermosifiliogr"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/01634989-199006000-00005"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1988.tb02872.x"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/49.1.51"},{"key":"e_1_2_6_58_1","first-page":"577","article-title":"Two case reports of delayed skin burns from methylisothiazolines used in water treatment","volume":"37","author":"Ng C K","year":"1996","journal-title":"Singapore Med J"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1992.tb05218.x"},{"key":"e_1_2_6_60_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2340\/0001555567315320","article-title":"Contact allergy to the active ingredients of Kathon CG in the guinea pig","volume":"67","author":"Bruze M","year":"1987","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01168.x"},{"key":"e_1_2_6_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10253.x"},{"key":"e_1_2_6_63_1","first-page":"1029","volume-title":"Contact Dermatitis","author":"Frosch P J","year":"2010"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12235","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:59:59Z","timestamp":1696615199000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,22]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/cod.12235"],"URL":"https:\/\/doi.org\/10.1111\/cod.12235","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,22]]}}}