{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:26:55Z","timestamp":1772224015941,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T00:00:00Z","timestamp":1397001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Methylchloroisothiazolinone (<jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>)\/methylisothiazolinone (<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>) in aqua is present in the <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean baseline patch test series at 100\u2009ppm, whereas 200\u2009ppm has been used in <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>weden since 1986, in <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>pain in the late 1980s, and, in recent years, also in the <jats:styled-content style=\"fixed-case\">U<\/jats:styled-content>nited <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ingdom and <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>reland.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>With regard to <jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content>, to investigate the data on contact allergy rates in dermatitis patients, the frequencies of allergic contact dermatitis in the same group, and adverse reactions, particularly patch test sensitization in tested dermatitis patients, and to find the optimal patch test concentration as dose in mg\/cm<jats:sup>2<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We performed a survey of the literature found via the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ational <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ibrary of <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edicine (<jats:styled-content style=\"fixed-case\">PubMed<\/jats:styled-content>, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed<\/jats:ext-link>, last accessed 20 February 2014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> at 200\u2009ppm aq. diagnosis substantially more contact allergy and allergic contact dermatitis, without any registered increase in patch test sensitization, than the presently used concentration of 100\u2009ppm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MCI<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MI<\/jats:styled-content> at 200\u2009ppm aq. is recommended to be included in the <jats:styled-content style=\"fixed-case\">E<\/jats:styled-content>uropean baseline patch test series. To avoid patch test sensitization, a dose of 0.006\u2009mg\/cm<jats:sup>2<\/jats:sup> must not be exceeded, which means a volume of 15\u2009\u00b5l for <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>inn <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hambers<jats:sup>\u00ae<\/jats:sup> (\u00d8 8\u2009mm).<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12240","type":"journal-article","created":{"date-parts":[[2014,4,9]],"date-time":"2014-04-09T09:52:45Z","timestamp":1397037165000},"page":"35-40","source":"Crossref","is-referenced-by-count":52,"title":["Recommendation to increase the test concentration of methylchloroisothiazolinone\/methylisothiazolinone in the <scp>E<\/scp>uropean baseline patch test series\u2009\u2013\u2009on behalf of the <scp>E<\/scp>uropean <scp>S<\/scp>ociety of <scp>C<\/scp>ontact <scp>D<\/scp>ermatitis and the <scp>E<\/scp>uropean <scp>E<\/scp>nvironmental and <scp>C<\/scp>ontact <scp>D<\/scp>ermatitis <scp>R<\/scp>esearch <scp>G<\/scp>roup"],"prefix":"10.1111","volume":"71","author":[{"given":"Magnus","family":"Bruze","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University  SE 205 02 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An","family":"Goossens","sequence":"additional","affiliation":[{"name":"Contact Allergy Unit, Department of Dermatology U.Z.K.U.  Leuven 3000 Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marl\u00e9ne","family":"Isaksson","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University  SE 205 02 Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,4,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06154.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12150"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12148"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01292.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00482.x"},{"key":"e_1_2_7_7_1","unstructured":"Commission Directive 2007\/17\/EC of 22 March 2007."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2004.04017"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01161.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1988.tb02965.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1985.tb02557.x"},{"key":"e_1_2_7_12_1","first-page":"283","volume-title":"Exogenous Dermatoses: Environmental Dermatitis","author":"Bruze M","year":"1990"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1986.tb01166.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1988.tb02923.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1985.tb01057.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2003.00170.x"},{"key":"e_1_2_7_17_1","unstructured":"Regulation (EC) No. 1223\/2009 of the European Parliament and the Council of 30 November 2009 on cosmetic products."},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02157.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02140.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2012.00958.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2011.627522"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e318277ca50"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01572.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.460404.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1991.tb01797.x"},{"key":"e_1_2_7_26_1","unstructured":"BruzeM IsakssonM GruvbergerBet\u2009al.Patch testing with methylchloroisothiazolinone\/methylisothiazolinone in water at 200\u2009ppm detects significantly more contact allergy than 100\u2009ppm. 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