{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:49:36Z","timestamp":1782125376465,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T00:00:00Z","timestamp":1400716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,8]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Hair dye exposure is the most common cause of sensitization to p<\/jats:italic>\u2010phenylenediamine (PPD<\/jats:styled-content>). Cross\u2010reactions with structurally related allergens occur.<\/jats:p><\/jats:sec>Objectives<\/jats:title>It is suggested that a stronger patch test reaction (3+ rather than 1+) to PPD<\/jats:styled-content> (usually tested as 1% petrolatum) is associated with an increased propensity for cross\u2010reactions. In this article we will demonstrate this association.<\/jats:p><\/jats:sec>Methods<\/jats:title>Of 230 patients with allergic reactions to PPD<\/jats:styled-content> on patch testing identified during 2007\u20132012 from clinical records, notes for 221 were available for review. Data were collected regarding age, sex, and grade of reaction [International Contact Dermatitis Research Group (ICDRG<\/jats:styled-content>) criteria] to PPD<\/jats:styled-content>. Cross\u2010reactions with the following allergens, found in our baseline series, were recorded: D<\/jats:styled-content>isperse Y<\/jats:styled-content>ellow 3, N<\/jats:italic><\/jats:styled-content>\u2010isopropyl\u2010N<\/jats:italic><\/jats:styled-content>\u2032<\/jats:italic>\u2010phenyl\u2010p<\/jats:italic>\u2010phenylenediamine (IPPD<\/jats:styled-content>), and caine mix. Having excluded 23 doubtful reactions, the reactions from 198 patients were further considered.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the patients, 75.3% (n\u2009=\u2009149) were female, and the mean age was 48.6\u2009years (12\u201382\u2009years). Of the patients allergic to PPD<\/jats:styled-content>, 16.6% (n\u2009=\u200933) showed cross\u2010reactions with one or more related allergens. Cross\u2010reactions were seen in 16% with a grade of 1+, 14.5% with a grade of 2+, 28.6% with a grade of 3+ when PPD<\/jats:styled-content> was tested 1% pet., and 50.0% when PPD<\/jats:styled-content> was tested at 0.1\u20130.001%, arbitrarily considered to be 4+ (p<\/jats:italic>\u2009=\u20090.02; Cram\u00e9r's V<\/jats:italic>\u2009=\u20090.23).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>An increasing likelihood of reactions to D<\/jats:styled-content>isperse Y<\/jats:styled-content>ellow 3, IPPD<\/jats:styled-content> or caine mix was seen with increasing strength of patch test reaction to PPD<\/jats:styled-content>. The clinical relevance of these cross\u2010reactions is unclear.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12255","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T07:38:38Z","timestamp":1400744318000},"page":"98-101","source":"Crossref","is-referenced-by-count":35,"title":["Positive relationship\u2009\u2013\u2009intensity of response to p<\/i>\u2010phenylenediamine on patch testing and cross\u2010reactions with related allergens"],"prefix":"10.1111","volume":"71","author":[{"given":"Bjorn R.","family":"Thomas","sequence":"first","affiliation":[{"name":"Department of Cutaneous Allergy St John's Institute of Dermatology London SE1 7EH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Allergy St John's Institute of Dermatology London SE1 7EH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"McFadden","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Allergy St John's Institute of Dermatology London SE1 7EH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piu","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Allergy St John's Institute of Dermatology London SE1 7EH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,5,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-55706-4"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2010.11.011"},{"key":"e_1_2_5_4_1","first-page":"332","article-title":"A 10\u2010year review of p\u2010phenylenediamine allergy and related para\u2010amino compounds at the Ottawa patch test clinic","volume":"6","author":"LaBerge L","year":"2011","journal-title":"Dermatitis"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.00779.x"},{"key":"e_1_2_5_6_1","first-page":"3","article-title":"The 44th clean survey on hair color and hair coloring","volume":"16","author":"Japan Soap and Detergent Association","year":"2002","journal-title":"Japan Soap and Dtergent News"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470508.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06742.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.3109\/15569527.2011.641195"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2003.00049.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00420.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2006.06026"},{"key":"e_1_2_5_13_1","first-page":"287","article-title":"Terminology of contact dermatitis","volume":"50","author":"Wilkinson D S","year":"1970","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1398-9995.2001.00086.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08644.x"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1977.tb03580.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03827-3"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450405.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12255","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T18:00:06Z","timestamp":1696615206000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,22]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/cod.12255"],"URL":"https:\/\/doi.org\/10.1111\/cod.12255","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,22]]}}}