{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:03:29Z","timestamp":1787321009680,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,9]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Drug patch tests (\n DPT<\/jats:styled-content>\n s) with medicaments suspected of causing an allergic reaction represent a method of diagnostic testing that is low risk;\n DPT<\/jats:styled-content>\n s can reproduce delayed hypersensitivity to drugs, and entail only a moderate re\u2010exposure of patients to potential offending drugs. We assessed the non\u2010irritating concentrations of\n DPT<\/jats:styled-content>\n s and determined the amounts of active ingredient (\n AI<\/jats:styled-content>\n ) contained in the drugs used in the tests.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n The objectives were to assess the non\u2010irritating concentration of DPTs and determine the amounts of active ingredient (AI) contained in the drugs used in the tests.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n From a retrospective, single\u2010centre study of all patients investigated during a 6\u2010year period with a drug eruption, each potentially responsible drug was tested with the commercially available preparation diluted to 30% in water, petrolatum, or alcohol. Data collection was performed with a customized computer database. For each type of\n DPT<\/jats:styled-content>\n studied, the numbers of positive and negative test results were recorded. The amount of\n AI<\/jats:styled-content>\n contained in the\n DPT<\/jats:styled-content>\n (as a percentage) was then calculated after weighing of each tablet.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of the 5558\n DPT<\/jats:styled-content>\n s studied, all were non\u2010irritant. The average concentration of\n AI<\/jats:styled-content>\n was 9.8%; 25% of\n DPT<\/jats:styled-content>\n s had an\n AI<\/jats:styled-content>\n concentration of < 2%, and 25% had an\n AI<\/jats:styled-content>\n concentration of > 16%. The\n AI<\/jats:styled-content>\n concentration ranged from 0.05% (digoxin) to 30% (paracetamol lyophilisate).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n These data provide thresholds for the non\u2010irritating concentration of\n AI<\/jats:styled-content>\n of 68 different drugs, and thresholds for the non\u2010irritating dilution for 82 drugs, and will help to standardize\n DPT<\/jats:styled-content>\n methods.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cod.12269","type":"journal-article","created":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T21:38:24Z","timestamp":1404250704000},"page":"170-175","source":"Crossref","is-referenced-by-count":44,"title":["Non\u2010irritant concentrations and amounts of active ingredient in drug patch tests"],"prefix":"10.1111","volume":"71","author":[{"given":"Delphine","family":"Brajon","sequence":"first","affiliation":[{"name":"Dermatology and Allergy Department Brabois Hospital, Batiment des Specialites Medicales, University Hospital of Nancy Rue du Morvan 54500 Vandoeuvre les Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Menetre","sequence":"additional","affiliation":[{"name":"Pharmacy Department Brabois Hospital, University Hospital of Nancy Rue du Morvan 54500 Vandoeuvre les Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Waton","sequence":"additional","affiliation":[{"name":"Dermatology and Allergy Department Brabois Hospital, Batiment des Specialites Medicales, University Hospital of Nancy Rue du Morvan 54500 Vandoeuvre les Nancy France"},{"name":"Faculte de Medecine, Research Unit EA 72\u201098 \u2018INGRES\u2019, Lorraine University 54500 Vandoeuvre les Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Poreaux","sequence":"additional","affiliation":[{"name":"Dermatology and Allergy Department Brabois Hospital, Batiment des Specialites Medicales, University Hospital of Nancy Rue du Morvan 54500 Vandoeuvre les Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Barbaud","sequence":"additional","affiliation":[{"name":"Dermatology and Allergy Department Brabois Hospital, Batiment des Specialites Medicales, University Hospital of Nancy Rue du Morvan 54500 Vandoeuvre les Nancy France"},{"name":"Faculte de Medecine, Research Unit EA 72\u201098 \u2018INGRES\u2019, Lorraine University 54500 Vandoeuvre les Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12125"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2009.04.010"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2009.02183.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2012.01409.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04418.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01946.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06429.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450502.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00452.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450601.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1586\/17469872.2.4.481"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470208.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.0105-4538.2001.00001.x-i8","article-title":"General considerations for skin test procedures in the diagnosis of drug hypersensitivity","volume":"57","author":"Brockow K","year":"2002","journal-title":"Allergy"},{"key":"e_1_2_6_15_1","first-page":"1","volume-title":"Diagnostic de l'allergie aux m\u00e9dicaments","author":"Commun N","year":"2005"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02313.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01659.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02689.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08975.x"}],"container-title":["Contact 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