{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:31:10Z","timestamp":1792798270663,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T00:00:00Z","timestamp":1405641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Aage Bangs Foundation"},{"name":"The Danish Medical Research Council"},{"DOI":"10.13039\/501100008271","name":"The LEO Pharma Research foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008271","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Lundbeck Foundation","id":[{"id":"https:\/\/ror.org\/03hz8wd80","id-type":"ROR","asserted-by":"crossref"}]},{"name":"The Novo Nordisk Foundation","id":[{"id":"https:\/\/ror.org\/04txyc737","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Several attempts to establish a model in mice that reflects nickel allergy in humans have been made. Most models use intradermal injection of nickel in combination with adjuvant to induce nickel allergy. However, such models poorly reflect induction of nickel allergy following long\u2010lasting epicutaneous exposure to nickel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To develop a mouse model reflecting nickel allergy in humans induced by epicutaneous exposure to nickel, and to investigate the mechanisms involved in such allergic responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Mice were exposed to\n                      <jats:styled-content style=\"fixed-case\">\n                        NiCl\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:styled-content>\n                      on the dorsal side of the ears. Inflammation was evaluated by the swelling and cell infiltration of the ears. T cell responses were determined as numbers of\n                      <jats:styled-content style=\"fixed-case\">\n                        CD4\n                        <jats:sup>+<\/jats:sup>\n                      <\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">\n                        CD8\n                        <jats:sup>+<\/jats:sup>\n                      <\/jats:styled-content>\n                      T cells in the draining lymph nodes. Localization of nickel was examined by dimethylglyoxime staining.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Epicutaneous exposure to nickel results in prolonged localization of nickel in the epidermis, and induces nickel allergy in mice. The allergic response to nickel following epicutaneous exposure is\n                      <jats:styled-content style=\"fixed-case\">MyD88<\/jats:styled-content>\n                      \u2010dependent and interleukin (\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      )\u20101 receptor\u2010dependent, but independent of toll\u2010like receptor (\n                      <jats:styled-content style=\"fixed-case\">TLR<\/jats:styled-content>\n                      )\u20104.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This new model for nickel allergy that reflects epicutaneous exposure to nickel in humans shows that nickel allergy is dependent on\n                      <jats:styled-content style=\"fixed-case\">MyD88<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20101 receptor signalling, but independent of\n                      <jats:styled-content style=\"fixed-case\">TLR4<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.12270","type":"journal-article","created":{"date-parts":[[2014,7,18]],"date-time":"2014-07-18T01:38:15Z","timestamp":1405647495000},"page":"224-232","source":"Crossref","is-referenced-by-count":34,"title":["Epicutaneous exposure to nickel induces nickel allergy in mice via a\n                    <scp>MyD88<\/scp>\n                    \u2010dependent and interleukin\u20101\u2010dependent pathway"],"prefix":"10.1111","volume":"71","author":[{"given":"Marie T.","family":"Vennegaard","sequence":"first","affiliation":[{"name":"Department of International Health, Immunology and Microbiology Faculty of Health and Medical Sciences, University of Copenhagen  DK\u20102200 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Dyring\u2010Andersen","sequence":"additional","affiliation":[{"name":"Department of International Health, Immunology and Microbiology Faculty of Health and Medical Sciences, University of Copenhagen  DK\u20102200 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology Copenhagen University Hospital Gentofte  DK\u20102900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morten M.","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of International Health, Immunology and Microbiology Faculty of Health and Medical Sciences, University of Copenhagen  DK\u20102200 Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas 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