{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:31:08Z","timestamp":1790886668307,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T00:00:00Z","timestamp":1407369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Astma och allergif\u00ef\u00bf\u00bdrbundet, Sweden"},{"name":"Hudfonden (Welander-Finsen Foundation), Sweden"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n R<\/jats:italic>\n \u2010Limonene is a common fragrance terpene found in domestic and industrial products.\n R<\/jats:italic>\n \u2010\n L<\/jats:styled-content>\n imonene autoxidizes on air exposure, and the oxidation products can cause contact allergy. In a recent multicentre study, 5.2% (range 2.3\u201312.1%) of 2900 patients showed a positive patch test reaction to oxidized\n R<\/jats:italic>\n \u2010limonene.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To study the exposure to limonene among consecutive dermatitis patients reacting to oxidized\n R<\/jats:italic>\n \u2010limonene in an international setting, and to assess the relevance of the exposure for the patients' dermatitis.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Oxidized\n R<\/jats:italic>\n \u2010limonene 3.0% (containing limonene hydroperoxides at 0.33%) in petrolatum was tested in 2900 consecutive dermatitis patients in\n A<\/jats:styled-content>\n ustralia,\n D<\/jats:styled-content>\n enmark, the\n U<\/jats:styled-content>\n nited\n K<\/jats:styled-content>\n ingdom,\n S<\/jats:styled-content>\n ingapore,\n S<\/jats:styled-content>\n pain, and\n S<\/jats:styled-content>\n weden. A questionnaire assessing exposure to limonene\u2010containing products was completed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Overall, exposure to products containing limonene was found and assessed as being probably relevant for the patients' dermatitis in 36% of the limonene\u2010allergic patients. In\n B<\/jats:styled-content>\n arcelona and\n C<\/jats:styled-content>\n openhagen, >\u200970% of the patients were judged to have had an exposure to limonene assessed as relevant.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Oxidized\n R<\/jats:italic>\n \u2010limonene is a common fragrance allergen, and limonene was frequently found in the labelling on the patients' products, and assessed as relevant for the patients' dermatitis. A large number of domestic and occupational sources for contact with\n R<\/jats:italic>\n \u2010limonene were identified.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cod.12285","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T02:00:46Z","timestamp":1407376846000},"page":"264-272","source":"Crossref","is-referenced-by-count":35,"title":["Positive patch test reactions to oxidized limonene: exposure and relevance"],"prefix":"10.1111","volume":"71","author":[{"given":"Johanna","family":"Br\u00e5red Christensson","sequence":"first","affiliation":[{"name":"Department of Dermatology Sahlgrenska Academy at the University of Gothenburg 405 30 Gothenburg Sweden"},{"name":"Dermatochemistry and Skin Allergy, Department of Chemistry and Molecular Biology University of Gothenburg 412 96 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Odense University Hospital, University of Southern Denmark DK\u20105000 Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University 205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology The National Allergy Research Centre, Gentofte Hospital, University of Copenhagen 2900 Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bego\u00f1a","family":"Garcia\u2010Bravo","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Virgen Macarena 41007 Seville Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Gimenez Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar, Universitat Aut\u00f2noma 08003 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee\u2010Leok","family":"Goh","sequence":"additional","affiliation":[{"name":"National Skin Centre 308205 Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary","family":"Nixon","sequence":"additional","affiliation":[{"name":"Occupational Dermatology Research and Education Centre, Skin and Cancer Foundation Melbourne 3053 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian R.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Allergy St John's Institute of Dermatology, St Thomas' Hospital London SE1 7EH 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