{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:03:49Z","timestamp":1773173029596,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T00:00:00Z","timestamp":1408579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>In recent years, the prevalence of contact allergy to isothiazolinones has reached epidemic levels. Few studies have presented data on occupations at risk of developing contact allergy to isothiazolinones.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To present demographics and examine risk factors for sensitization to methylisothiazolinone (MI<\/jats:styled-content>), methylchloroisothiazolinone (MCI<\/jats:styled-content>) in combination with MI<\/jats:styled-content> and benzisothiazolinone (BIT<\/jats:styled-content>) in D<\/jats:styled-content>anish dermatitis patients.<\/jats:p><\/jats:sec>Materials and methods<\/jats:title>A retrospective epidemiological analysis of data from three D<\/jats:styled-content>anish hospitals departments was conducted. All patients consecutively patch tested with MI<\/jats:styled-content>, MCI<\/jats:styled-content>\/MI<\/jats:styled-content> and BIT<\/jats:styled-content> between 2009 and 2013 were included.<\/jats:p><\/jats:sec>Results<\/jats:title>MI<\/jats:styled-content> contact allergy showed a significantly increased trend in prevalence from 1.8% in 2009 to 4.2% in 2012 (p<\/jats:italic>\u2009<\u20090.001). Females with facial dermatitis mainly drove the increase in 2012. Adjusted logistic regression analysis showed that MI<\/jats:styled-content> sensitization was significantly associated with occupational exposures, hand and facial dermatitis, age >\u200940\u2009years, and the occupational groups of tile setters\/terrazzo workers, machine operators, and painters. MCI<\/jats:styled-content>\/MI<\/jats:styled-content> contact allergy was significantly associated with the following high\u2010risk occupations: painting, welding (blacksmiths), machine operating, and cosmetology. The occupational group of painting was frequent in the group of patients with BIT<\/jats:styled-content> contact allergy.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Several high\u2010risk occupations for sensitization to isothiazolinones exist. Regulation on the allowed concentration of isothiazolinones, and especially MI<\/jats:styled-content>, in both consumer products and industrial products is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12286","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T05:46:23Z","timestamp":1408599983000},"page":"295-302","source":"Crossref","is-referenced-by-count":56,"title":["Occupations at risk of developing contact allergy to isothiazolinones in D<\/scp>anish contact dermatitis patients: results from a D<\/scp>anish multicentre study (2009\u20132012)"],"prefix":"10.1111","volume":"71","author":[{"given":"Jakob F.","family":"Schwensen","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte 2900 Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torkil","family":"Menn\u00e9","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte 2900 Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital 5000 Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"Sommerlund","sequence":"additional","affiliation":[{"name":"Department of Dermatology Aarhus University Hospital 8000 Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte 2900 Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,21]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.01058.x"},{"key":"e_1_2_5_3_1","volume-title":"The Scientific Commitee on Cosmetic Products and Non\u2010Food Products Intended for Consumers Opinion Concerning Methylisothiazolinone (SCCNFP\/0625\/02 and 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