{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:15:21Z","timestamp":1791422121401,"version":"4.3.3"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T00:00:00Z","timestamp":1408579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Aage Bang Fond"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chromium\u2010tanned leather articles currently constitute the most important cause of contact allergy to chromium in <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>enmark. A regulation on the content of hexavalent chromium in leather was adopted in <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ovember 2013 by the <jats:styled-content style=\"fixed-case\">EU<\/jats:styled-content> member states.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To characterize patients with chromium allergy and their disease, to serve as a baseline for future studies on the potential effect of the new regulation on chromium in leather.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A questionnaire case\u2013control study was performed on 155 dermatitis patients with positive patch test reactions to potassium dichromate and a matched control group of 621 dermatitis patients. Comparisons were made by use of a <jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2010test and the <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ann\u2013<jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>hitney <jats:styled-content style=\"fixed-case\"><jats:italic>U<\/jats:italic><\/jats:styled-content>\u2010test. Logistic regression analyses were used to test for associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010six per cent of chromium\u2010allergic patients had a positive history of contact dermatitis caused by leather exposure. They had a significantly lower quality of life (<jats:italic>p<\/jats:italic> &lt; 0.001), a higher prevalence of dermatitis during the last year (<jats:italic>p<\/jats:italic> = 0.008), a higher use of medication during the past 12 months (<jats:italic>p<\/jats:italic> = 0.001) and a higher prevalence of sick leave (<jats:italic>p<\/jats:italic> = 0.007) than patients in the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Chromium\u2010allergic patients have more severe and more chronic contact dermatitis. Their primary chromium exposure comes from leather articles.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12291","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T05:44:51Z","timestamp":1408599891000},"page":"338-347","source":"Crossref","is-referenced-by-count":40,"title":["Characteristics of chromium\u2010allergic dermatitis patients prior to regulatory intervention for chromium in leather: a questionnaire study"],"prefix":"10.1111","volume":"71","author":[{"given":"David","family":"Bregnbak","sequence":"first","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte  Ledreborg All\u00e9 40, Gentofte 2820 Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Copenhagen University Hospital Gentofte  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