{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:18Z","timestamp":1787014038699,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T00:00:00Z","timestamp":1410393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Swedish Agreement concerning research and education of doctors"},{"name":"the Edvard Welander foundation"},{"name":"The Swedish Asthma and Allergy Associations Research Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The fragrance compound geraniol is susceptible to autoxidation when in contact with air, and to cutaneous metabolism. In both processes, the isomeric aldehydes geranial and neral are formed. Citral consists of geranial and neral. Among patients with positive reactions to citral, we have previously detected concomitant reactions to geraniol in 85% of cases and to oxidized geraniol in 73% of cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To study the pattern of concomitant reactions to geraniol and citral and its isomers geranial and neral, and to determine whether these isomers are important sensitizers in contact allergy to geraniol and oxidized geraniol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>The irritancy of geranial and citral was studied. Six hundred and fifty\u2010five patients were patch tested with geranial, neral and citral at 3.5% pet., pure geraniol at 6.0% and 11.0% pet., and oxidized geraniol at 6.0% pet.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Twenty\u2010six per cent of citral\u2010positive patients reacted to oxidized geraniol, and 10.5% reacted to pure geraniol. Citral and\/or its isomers gave positive reactions in 25% of the patients who reacted to pure geraniol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There is little cross\u2010reactivity between pure geraniol and citral; however, concomitant reactions to citral and oxidized geraniol were common, owing to geranial. Geranial was also the main sensitizer in the mixture citral.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.12293","type":"journal-article","created":{"date-parts":[[2014,9,11]],"date-time":"2014-09-11T08:01:00Z","timestamp":1410422460000},"page":"280-288","source":"Crossref","is-referenced-by-count":25,"title":["Cross\u2010reactivity between citral and geraniol\u2009\u2013\u2009can it be attributed to oxidized geraniol?"],"prefix":"10.1111","volume":"71","author":[{"given":"Lina","family":"Hagvall","sequence":"first","affiliation":[{"name":"Department of Dermatology Sahlgrenska Academy, University of Gothenburg  Gr\u00f6na Str\u00e5ket 16 413 45 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Br\u00e5red Christensson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sahlgrenska Academy, University of Gothenburg  Gr\u00f6na Str\u00e5ket 16 413 45 Gothenburg Sweden"},{"name":"Dermatochemistry and Skin Allergy, Department of Chemistry and Molecular Biology University of Gothenburg  Kemig\u00e5rden 4 412 96 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450406.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05633.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02246.x"},{"key":"e_1_2_7_5_1","first-page":"S1","article-title":"A toxicologic and dermatologic assessment of cyclic and non\u2010cyclic terpene alcohols when used as fragrance ingredients","volume":"46","author":"Belsito D","year":"2008","journal-title":"Food Chem Toxicol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00302.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01088.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx700017v"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1992.tb00129.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx049831z"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01262.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201200855"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annhyg\/38.2.199"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02134.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12036"},{"key":"e_1_2_7_16_1","unstructured":"Br\u00e5red ChristenssonJ AndersenK E BruzeMet al.Positive patch test reactions to oxidized limonene: exposure and relevance.Contact Dermatitis2014; 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