{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:49:32Z","timestamp":1782125372754,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T00:00:00Z","timestamp":1410998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Several of the ingredients in fragrance mix I (FM I<\/jats:styled-content>) have been shown to evaporate from petrolatum preparations applied in test chambers to an extent that can be suspected to affect the patch test result.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To compare the reactivity towards FM I<\/jats:styled-content> and fragrance mix II<\/jats:styled-content> (FM II<\/jats:styled-content>) when they are applied in test chambers in advance and immediately prior to the patch test occasion.<\/jats:p><\/jats:sec>Methods<\/jats:title>Seven hundred and ninety\u2010five consecutive patients were simultaneously patch tested with duplicate samples of FM I<\/jats:styled-content> and FM II<\/jats:styled-content>. One sample was applied in the test chamber 6\u2009days in advance (6D<\/jats:styled-content> sample), and the other sample was applied immediately before the patients were patch tested (fresh sample).<\/jats:p><\/jats:sec>Results<\/jats:title>Twenty\u2010two (2.8%) patients reacted exclusively to the fresh sample of FM I<\/jats:styled-content>, 6 (0.7%) reacted exclusively to the 6D<\/jats:styled-content> sample, and 22 (2.8%) reacted to both samples. The corresponding numbers for FM II<\/jats:styled-content> were 9 (1.1%) for the fresh sample, 6 (0.7%) for the 6D<\/jats:styled-content> sample and 12 (1.5%) for both samples.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>There was a statistically significant difference between the numbers of patients reacting to the fresh and 6D<\/jats:styled-content> samples of FM I<\/jats:styled-content>. No corresponding difference was observed for FM II<\/jats:styled-content>. This can probably be explained by differences in volatilities between the ingredients of FM I<\/jats:styled-content> and FM II<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12300","type":"journal-article","created":{"date-parts":[[2014,9,18]],"date-time":"2014-09-18T06:04:17Z","timestamp":1411020257000},"page":"289-294","source":"Crossref","is-referenced-by-count":28,"title":["Fragrance patch tests prepared in advance may give false\u2010negative reactions"],"prefix":"10.1111","volume":"71","author":[{"given":"Martin","family":"Mowitz","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University SE\u2010205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Svedman","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University SE\u2010205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Zimerson","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University SE\u2010205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University SE\u2010205 02 Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11143.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02035.x"},{"key":"e_1_2_6_4_1","unstructured":"SvedmanC MowitzM ZimersonE Pont\u00e9nA HaukssonI IsakssonM Hinds\u00e9nM BruzeM.Patch testing with the baseline series and fragrance ingredients.2014(in manuscript)."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01098.x"},{"key":"e_1_2_6_6_1","first-page":"287","article-title":"Terminology of contact dermatitis","volume":"50","author":"Wilkinson D S","year":"1970","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01759.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12056"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07170.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb00834.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12171"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx700017v"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12009"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12234"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02167.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e318281d094"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10087.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12156"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12300","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12300","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T03:13:08Z","timestamp":1696389188000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,18]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/cod.12300"],"URL":"https:\/\/doi.org\/10.1111\/cod.12300","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,18]]}}}