{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:30:24Z","timestamp":1790505024661,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T00:00:00Z","timestamp":1412640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Modern dressings (<jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>s) may have a low sensitization rate, but there is a lack of prospective studies in patients with chronic leg ulcers (<jats:styled-content style=\"fixed-case\">CLU<\/jats:styled-content>s) to evaluate this.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the rate of sensitization (contact allergy) to <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>s and substances present in dressings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>A prospective multicentre study was carried out in patients with <jats:styled-content style=\"fixed-case\">CLU<\/jats:styled-content>s at five French dermatology departments; patch tests were performed with the European baseline series and with an additional 27 individual allergens and 10 <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 354 patients (226 women and 128 men) with <jats:styled-content style=\"fixed-case\">CLU<\/jats:styled-content>s, 59.6% had at least one positive patch test reaction to an <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content> and 19% had at least one sensitization to an <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>. The number of positive test reactions per patient was correlated with the duration of ulcerative disease, but not with ulcer duration, the cause of the ulcer, or the presence of surrounding eczematous lesions. For 11 of 45 patients sensitized to Ialuset cream<jats:sup>\u00ae<\/jats:sup>, more detailed information could be obtained with sensitization to sodium dehydroacetate (5 cases) or Lanette <jats:styled-content style=\"fixed-case\">SX<\/jats:styled-content><jats:sup>\u00ae<\/jats:sup> (3 cases).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sensitization to <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>s is not rare. It is absolutely necessary to label all components of <jats:styled-content style=\"fixed-case\">MD<\/jats:styled-content>s on their packaging and to avoid some sensitizing molecules, such as colophonium derivatives or any strong sensitizers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12307","type":"journal-article","created":{"date-parts":[[2014,10,7]],"date-time":"2014-10-07T08:51:22Z","timestamp":1412671882000},"page":"90-96","source":"Crossref","is-referenced-by-count":65,"title":["Contact sensitization to modern dressings: a multicentre study on 354 patients with chronic leg ulcers"],"prefix":"10.1111","volume":"72","author":[{"given":"Aude","family":"Valois","sequence":"first","affiliation":[{"name":"Dermatology and Allergy University Hospital of Nancy  rue du Morvan 54511 Vandoeuvre\u2010les\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Waton","sequence":"additional","affiliation":[{"name":"Dermatology and Allergy University Hospital of Nancy  rue du Morvan 54511 Vandoeuvre\u2010les\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine","family":"Avenel\u2010Audran","sequence":"additional","affiliation":[{"name":"Dermatology University of Angers  Rue Larrey 49100 Angers France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Truchetet","sequence":"additional","affiliation":[{"name":"Dermatology Regional Hospital of Metz\u2010Thionville  rue du Friscaty 57100 Thioville France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyne","family":"Collet","sequence":"additional","affiliation":[{"name":"Dermatology University Hospital of Dijon  rue Gaffarel 21079 Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Raison\u2010Peyron","sequence":"additional","affiliation":[{"name":"Dermatology University Hospital of Montpellier  Avenue du Doyen Gaston Giraud 34090 Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Francois","family":"Cuny","sequence":"additional","affiliation":[{"name":"Dermatology and Allergy University Hospital of Nancy  rue du Morvan 54511 Vandoeuvre\u2010les\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Bethune","sequence":"additional","affiliation":[{"name":"Laboratory for Statistics University Hospital of Nancy  rue du Morvan 54511 Vandoeuvre\u2010les\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Luc","family":"Schmutz","sequence":"additional","affiliation":[{"name":"Dermatology and Allergy University Hospital of Nancy  rue du Morvan 54511 Vandoeuvre\u2010les\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annick","family":"Barbaud","sequence":"additional","affiliation":[{"name":"Dermatology and Allergy University Hospital of Nancy  rue du Morvan 54511 Vandoeuvre\u2010les\u2010Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of the Dermatology and Allergy group (GAD) of the French Society of Dermatology","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05917.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129334-200311000-00013"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000250570"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534734608322608"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01541.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01253.x"},{"key":"e_1_2_5_8_1","first-page":"694","article-title":"Sensibilisation de contact et ulc\u00e8res de jambe","volume":"125","author":"Le Coz C J","year":"1998","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.00987.x"},{"key":"e_1_2_5_10_1","first-page":"1133","article-title":"Sensibilizzazione da contatto nelle dermatiti da stasi e ulcere croniche degli arti inferiori. 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