{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:33:12Z","timestamp":1791405192647,"version":"4.3.3"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T00:00:00Z","timestamp":1414454400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Allergic contact dermatitis affects a worrying proportion of the general population. The mechanisms underlying this chemical\u2010triggered delayed\u2010type hypersensitivity are still not fully understood. In recent years, basic research has shown that the immune system reacts to contact allergens by activation of signalling pathways that are usually used to fight infections. Ongoing work is aimed at the elucidation of the path that leads from the chemistry of contact allergens to the inflammatory skin disease. The cellular players and their complex interactions are being characterized. Proteins are being identified whose chemical modification by contact allergens results in the activation of signalling pathways involved in pathogenesis. Pathway identification is supported by genomic and proteomic techniques. All of these efforts will yield a cellular and molecular understanding of the orchestration of the innate and adaptive immune response to contact allergens. This knowledge will help in the identification of gene and protein signatures for improved diagnostics, the identification of novel drug targets for targeted treatments, as well the development of\n                    <jats:italic>in\u2009vitro<\/jats:italic>\n                    assays for contact allergen identification.\n                  <\/jats:p>","DOI":"10.1111\/cod.12311","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T06:24:55Z","timestamp":1414477495000},"page":"2-10","source":"Crossref","is-referenced-by-count":99,"title":["New concepts in cutaneous allergy"],"prefix":"10.1111","volume":"72","author":[{"given":"Stefan F.","family":"Martin","sequence":"first","affiliation":[{"name":"Allergy Research Group, Department of Dermatology Medical Centre \u2010 University of Freiburg  Hauptstrasse 7 D\u201079104 Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,10,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0846-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/ddg.12371","article-title":"Current trends in patch testing\u2009\u2013\u2009new data from the German Contact Dermatitis Research Group (DKG) and the Information Network of Departments of Dermatology (IVDK)","volume":"12","author":"Mahler V","year":"2014","journal-title":"J Dtsch Dermatol Ges =J Ger Soc Dermatol: JDDG"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0495-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.05.022"},{"key":"e_1_2_9_6_1","first-page":"101","article-title":"Correlation of contact sensitizer potency with T cell frequency and TCR repertoire diversity","volume":"104","author":"Esser P R","year":"2014","journal-title":"EXS"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI40926"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00332"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2012.05.013"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2013.10.013"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2012.08.003"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx050075m"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx700024w"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx060121y"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/2050-6511-15-5"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2012.01471.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2009.05.001"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.46.120604.141046"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.02.008"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-012-0976-2"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kft084"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2010.03.009"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-030212-183811"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609598103"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05544"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn2056"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2011.03.017"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-229948"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1919"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2012.155"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12042"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2011.02.015"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2012.05.019"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2012.08.023"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2014.03.009"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008946"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.03.028"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0304193"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122220"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63986-7"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1071059"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02652.x"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4755"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67947"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20070509"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092489"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041340"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.09.008"},{"key":"e_1_2_9_49_1","first-page":"305","article-title":"Acetaminophen\u2010induced hepatotoxicity in mice is dependent on Tlr9 and the Nalp3 inflammasome","volume":"119","author":"Imaeda A B","year":"2009","journal-title":"J Clin Invest"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00352.2011"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12018"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1003930"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10.162438"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-014-1676-2"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02705.x"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00342.x"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01945.x"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12125"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12165"},{"key":"e_1_2_9_60_1","article-title":"Coupled exposure to ingredients of cosmetic products: III. Ultraviolet filters","author":"Uter W","year":"2014","journal-title":"Contact Dermatitis"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfu047"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02083.x"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx300428u"},{"key":"e_1_2_9_64_1","first-page":"145","volume-title":"Progress Towards Novel Testing Strategies for in Vitro Assessment of Allergens","author":"Thierse H J","year":"2012"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.11.016"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx5000624"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02004_2.x"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02004_3.x"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.02004_4.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12311","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12311","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:28:24Z","timestamp":1696303704000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10,28]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["10.1111\/cod.12311"],"URL":"https:\/\/doi.org\/10.1111\/cod.12311","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,10,28]]}}}