{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:19:13Z","timestamp":1772223553688,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T00:00:00Z","timestamp":1421020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sunflowers may cause dermatitis because of allergenic sesquiterpene lactones (<jats:styled-content style=\"fixed-case\">SLs<\/jats:styled-content>). Contact sensitization to sunflower seeds has also been reported, but the allergens are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyse sunflower seeds for the presence of <jats:styled-content style=\"fixed-case\">SLs<\/jats:styled-content> and to assess the prevalence of sunflower sensitization in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ompositae\u2010allergic individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/materials\/methods<\/jats:title><jats:p>Sunflower\u2010sensitive patients were identified by aimed patch testing. A dichloromethane extract of whole sunflower seeds was analysed by liquid chromatography\u2010mass spectrometry and high\u2010performance liquid chromatography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of sensitivity to sunflower in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ompositae\u2010allergic individuals was 56%. A solvent wash of whole sunflower seeds yielded an extract containing <jats:styled-content style=\"fixed-case\">SLs<\/jats:styled-content>, the principal component tentatively being identified as argophyllin <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>, other <jats:styled-content style=\"fixed-case\">SLs<\/jats:styled-content> being present in minute amounts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The concentration of <jats:styled-content style=\"fixed-case\">SLs<\/jats:styled-content> on the sunflower seeds is considered high enough to elicit dermatitis in sensitive persons, and it seems appropriate to warn <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ompositae\u2010allergic subjects against handling sunflower seeds.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12326","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T10:18:34Z","timestamp":1421057914000},"page":"172-177","source":"Crossref","is-referenced-by-count":17,"title":["Sunflower seeds as eliciting agents of Compositae dermatitis"],"prefix":"10.1111","volume":"72","author":[{"given":"Evy","family":"Paulsen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark  Sdr. Boulevard 29 DK\u20105000 Odense C Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rime B.","family":"El\u2010Houri","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Biotechnology and Environmental Technology University of Southern Denmark  Campusvej 55 DK\u20105230 Odense M Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark  Sdr. 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