{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:18Z","timestamp":1787014038746,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T00:00:00Z","timestamp":1422316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Linalyl acetate is a fragrance chemical that is prone to autoxidation. Exposure to linalyl acetate occurs through cosmetic products and essential oils, but is difficult to assess, as linalyl acetate is not labelled in the\n                      <jats:styled-content style=\"fixed-case\">EU<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the frequencies of contact allergy to oxidized linalyl acetate among dermatitis patients, and to investigate the autoxidation of linalyl acetate in terms of hydroperoxide formation and sensitization potency.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>Hydroperoxide formation in air\u2010exposed linalyl acetate was determined with high\u2010performance liquid chromatography. The sensitization potencies of hydroperoxides were determined with the local lymph node assay. One thousand seven hundred and seventeen patients were patch tested with oxidized linalyl acetate at 6.0% in petrolatum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the patients, 2.2% showed positive reactions to oxidized linalyl acetate. Forty\u2010three per cent of the positive patients also had positive patch test reactions to other fragrance markers. Linalyl acetate hydroperoxides were detected early in the autoxidation process, and accumulated to a concentration of 37% after 42 weeks of air exposure. The linalyl acetate hydroperoxides were classified as moderate sensitizers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The frequency of positive reactions to oxidized linalyl acetate is comparable to that of previously studied oxidized fragrance terpenes. Oxidized linalyl acetate could thus be a common fragrance contact allergen.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.12350","type":"journal-article","created":{"date-parts":[[2015,1,27]],"date-time":"2015-01-27T01:54:12Z","timestamp":1422323652000},"page":"216-223","source":"Crossref","is-referenced-by-count":26,"title":["Air\u2010oxidized linalyl acetate \u2013 an emerging fragrance allergen?"],"prefix":"10.1111","volume":"72","author":[{"given":"Lina","family":"Hagvall","sequence":"first","affiliation":[{"name":"Department of Dermatology Sahlgrenska Academy, University of Gothenburg  Gr\u00f6na str\u00e5ket 16, 413 45 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Berglund","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sahlgrenska Academy, University of Gothenburg  Gr\u00f6na str\u00e5ket 16, 413 45 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Br\u00e5red Christensson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sahlgrenska Academy, University of Gothenburg  Gr\u00f6na str\u00e5ket 16, 413 45 Gothenburg Sweden"},{"name":"Dermatochemistry and Skin Allergy, Department of Chemistry and Molecular Biology University of Gothenburg  Kemiv\u00e4gen 10, 412 96 Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(03)00014-0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450406.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05633.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(03)00016-4"},{"key":"e_1_2_7_6_1","first-page":"117","article-title":"Lavender essential oil: standardisation, ISO; adulteration and its detection using GC, enantiomeric columns and bioactivity","volume":"29","author":"Lis\u2010Balchin M","year":"2002","journal-title":"Med Aromatic Plants Ind Profiles"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01402.x"},{"key":"e_1_2_7_8_1","first-page":"200","article-title":"Miscellaneous uses of lavender and lavender oil. 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