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A great number of molecules and pathways can contribute to the perturbation by xenobiotics and the subsequent possible immune response. It is necessary to consider susceptibility in two ways: as allergen\u2010specific and as non\u2010allergen\u2010specific. It is likely that different receptor pathways and processes will be involved in the different forms of susceptibility. As investigations of the genetic control of such susceptibility have failed to identify major genetic control, it is likely that small contributions will be made by many components. Whereas genome\u2010wide associations and transcriptome analyses may reveal genetic clues in the future, explanation of how\/why the expression of multiple molecular components can be controlled in a coordinated fashion may follow from investigation of <jats:styled-content style=\"fixed-case\">microRNAs<\/jats:styled-content>. It is becoming clear that <jats:styled-content style=\"fixed-case\">microRNAs<\/jats:styled-content> can regulate the expression of multiple genes and even multiple components of biochemical pathways.<\/jats:p>","DOI":"10.1111\/cod.12362","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T05:41:21Z","timestamp":1424842881000},"page":"263-274","source":"Crossref","is-referenced-by-count":38,"title":["Genetic factors in susceptibility to contact sensitivity"],"prefix":"10.1111","volume":"72","author":[{"given":"Peter S.","family":"Friedmann","sequence":"first","affiliation":[{"name":"Division of Infection, Inflammation &amp; Immunity, Sir Henry Wellcome Laboratories Southampton University Hospitals NHS Trust  Southampton SO16 6YD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilman","family":"Sanchez\u2010Elsner","sequence":"additional","affiliation":[{"name":"Division of Infection, Inflammation &amp; Immunity, Sir Henry Wellcome Laboratories Southampton University Hospitals NHS Trust  Southampton SO16 6YD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Schnuch","sequence":"additional","affiliation":[{"name":"IVDK a.d. 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