{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T21:26:40Z","timestamp":1772054800897,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2015,6]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Sensitivity to either methylchloroisothiazolinone (MCI<\/jats:styled-content>)\/methylisothiazolinone (MI<\/jats:styled-content>) or MI<\/jats:styled-content> has increased, with a reported frequency of up to 11.1% among dermatitis patients, the main context being allergic contact dermatitis caused by MCI<\/jats:styled-content> or MCI<\/jats:styled-content>\/MI<\/jats:styled-content> in personal care products. Case reports have described occupational allergic contact dermatitis caused by MI<\/jats:styled-content> in paints and within the beauty industry.<\/jats:p><\/jats:sec>Patients\/materials\/methods<\/jats:title>This study identified incident cases of occupational allergic contact dermatitis caused by MCI<\/jats:styled-content>\/MI<\/jats:styled-content> and or MI<\/jats:styled-content> reported from 1996 to 2012 to a UK<\/jats:styled-content>\u2010wide surveillance scheme (EPIDERM<\/jats:styled-content>), with the aim of identifying changes in incidence over the study period.<\/jats:p><\/jats:sec>Results<\/jats:title>The data show an increase in occupational allergic contact dermatitis caused by MCI<\/jats:styled-content>\/MI<\/jats:styled-content> and or MI<\/jats:styled-content> from 1996 to 2012 of 4.1% [95% confidence interval (CI<\/jats:styled-content>) 1.6\u20136.9] per annum. Analysis by industry showed a 3.8% (95% CI:<\/jats:styled-content> \u22120.3 to 8.0) per annum increase in those exposed to personal care products in the workplace as a primary exposure [healthcare workers, 8.1% (95% CI:<\/jats:styled-content> 2.1\u201314.4) per annum; beauty workers, 6.6% (95% CI:<\/jats:styled-content> \u22122.2 to 16.2) per annum; hairdressers, 1.5% (95% CI:<\/jats:styled-content> \u22124.7 to 8.1) per annum]. There was a 6.3% (95% CI:<\/jats:styled-content> 1.8\u201310.9) per annum increase for manufacturing workers. A statistically significant rise in the frequency of occupational allergic contact dermatitis was shown to be attributable to MCI<\/jats:styled-content>\/MI<\/jats:styled-content> and or MI<\/jats:styled-content> between 1996 and 2012.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The findings support recommendations for a review of the regulations relating to MCI<\/jats:styled-content>\/MI<\/jats:styled-content> and\/or MI<\/jats:styled-content> in cosmetic and personal care products and in industrial settings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12379","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T11:04:03Z","timestamp":1427281443000},"page":"381-386","source":"Crossref","is-referenced-by-count":26,"title":["Methylchloroisothiazolinone and methylisothiazolinone contact allergy: an occupational perspective"],"prefix":"10.1111","volume":"72","author":[{"given":"Rachel","family":"Urwin","sequence":"first","affiliation":[{"name":"Leeds Centre for Dermatology, Chapel Allerton Hospital Leeds LS7 4SA UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharine","family":"Warburton","sequence":"additional","affiliation":[{"name":"Leeds Centre for Dermatology, Chapel Allerton Hospital Leeds LS7 4SA UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Carder","sequence":"additional","affiliation":[{"name":"Centre for Occupational and Environmental Health, Centre for Epidemiology, Institute of Population Health, Faculty of Medical and Human Sciences, The University of Manchester Manchester M13 9PL UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Turner","sequence":"additional","affiliation":[{"name":"Centre for Occupational and Environmental Health, Centre for Epidemiology, Institute of Population Health, Faculty of Medical and Human Sciences, The University of Manchester Manchester M13 9PL UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Agius","sequence":"additional","affiliation":[{"name":"Centre for Occupational and Environmental Health, Centre for Epidemiology, Institute of Population Health, Faculty of Medical and Human Sciences, The University of Manchester Manchester M13 9PL UK"},{"name":"St Mary's Hospital, Manchester Academic Health Science Centre, Central Manchester University Hospitals NHS Foundation Trust Manchester M13 9WL UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S Mark","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Leeds Centre for Dermatology, Chapel Allerton Hospital Leeds LS7 4SA UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12185"},{"key":"e_1_2_6_3_1","unstructured":"Scientific Committee on Consumer Safety opinion on Methylisothiazolinone (p94) submission II 0000. 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