{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:30:42Z","timestamp":1791282642467,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2015,7]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n In the 1980s, a striking increase in natural rubber latex (\n NRL<\/jats:styled-content>\n ) allergy was seen. Since then, many measures have been taken to prevent\n NRL<\/jats:styled-content>\n allergy.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To investigate changes in the prevalence of\n NRL<\/jats:styled-content>\n sensitization\/clinical\n NRL<\/jats:styled-content>\n allergy over time from 2002 to 2013.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n All patients prick tested for\n NRL<\/jats:styled-content>\n at the Department of Dermatology and Allergy Centre, Odense University Hospital were included in this study (n = 8580). In\n NRL<\/jats:styled-content>\n \u2010sensitized patients, the clinical relevance was evaluated for\n NRL<\/jats:styled-content>\n . Furthermore, concomitant positive prick test results for birch pollen were recorded, together with food\u2010related symptoms and sensitization in a subgroup of patients.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The prevalence of\n NRL<\/jats:styled-content>\n sensitization declined from 6.1% in 2002\u20132005 to 1.9% in 2006\u20132009, and then to 1.2% in 2010\u20132013 (\n p<\/jats:italic>\n < 0.0001). The prevalence of clinical\n NRL<\/jats:styled-content>\n allergy declined from 1.3% in 2002\u20132005 to 0.5\u20130.6% in 2006\u20132013 (\n p<\/jats:italic>\n < 0.004). Among the\n NRL<\/jats:styled-content>\n \u2010sensitized patients, 64% had a concomitant positive prick test reaction to birch pollen, and 52% had a history of reaction to oral intake of related fruits or vegetables.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Our study showed a statistically significant decline in the number of patients sensitized\/clinically allergic to\n NRL<\/jats:styled-content>\n . Many of the\n NRL<\/jats:styled-content>\n \u2010sensitized patients without clinical allergy to\n NRL<\/jats:styled-content>\n had concomitant birch pollen sensitization, and reported food\u2010related symptoms.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cod.12386","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T07:08:04Z","timestamp":1427267284000},"page":"21-28","source":"Crossref","is-referenced-by-count":53,"title":["Decrease in the rate of sensitization and clinical allergy to natural rubber latex"],"prefix":"10.1111","volume":"73","author":[{"given":"Michelle S. B.","family":"Blaabjerg","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark DK\u20105000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark DK\u20105000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Bindslev\u2010Jensen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark DK\u20105000 Odense C Denmark"},{"name":"Department of Dermatology and Allergy Centre Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital, University of Southern Denmark DK\u20105000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte G.","family":"Mortz","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark DK\u20105000 Odense C Denmark"},{"name":"Department of Dermatology and Allergy Centre Odense Research Centre for Anaphylaxis (ORCA), Odense University Hospital, University of Southern Denmark DK\u20105000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.125336"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323892"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/msj.20281"},{"key":"e_1_2_5_5_1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1159\/000358863","article-title":"The latex story","volume":"110","author":"Raulf M","year":"2014","journal-title":"Chem Immunol Allergy"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2006.02521.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-003-0012-y"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1979.tb15107.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.05.054"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.1108"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01842.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-004-0594-2"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.126461"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.125442"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.118792"},{"key":"e_1_2_5_16_1","first-page":"A5835","article-title":"Research into sensitization and allergies to latex: results after 10 years of the use of powder\u2010free latex gloves","volume":"157","author":"de Groot H","year":"2013","journal-title":"Ned Tijdschr Geneeskd"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-013-0885-6"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2010.02447.x"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-36866"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2012-100754"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0b013e31822589dc"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.120557"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03827-3"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.03.048"},{"key":"e_1_2_5_25_1","unstructured":"Danish Health and Medicines Authority.European Directives on medical devices 2014. Available at:http:\/\/sundhedsstyrelsen.dk\/en\/medicines\/medical\u2010devices\/legislation\u2010and\u2010guidance\/european\u2010directives(last assessed 09 October 2014)."},{"key":"e_1_2_5_26_1","unstructured":"Danish Health and Medicines Authority.Prevention of latex allergy. Statement and guidance 2003. Available at:http:\/\/sundhedsstyrelsen.dk\/publ\/publ2004\/latexallergi.pdf(last assessed 9 October 2014)."},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-7022-4-28"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12429"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12386","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12386","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T20:35:15Z","timestamp":1696278915000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,25]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["10.1111\/cod.12386"],"URL":"https:\/\/doi.org\/10.1111\/cod.12386","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,25]]}}}