{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:22:41Z","timestamp":1775470961910,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T00:00:00Z","timestamp":1434412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Contact allergy to fragrances is common, and impairs quality of life, particularly in young women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To provide current results on the prevalences of sensitization to fragrance allergens used as markers in the baseline series of most European countries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of patients consecutively patch tested between 2009 and 2012 in 12 European countries with fragrance allergens contained in the baseline series were collected by the European Surveillance System on Contact Allergies network and descriptively analysed. Four departments used the <jats:styled-content style=\"fixed-case\">TRUE T<\/jats:styled-content>est<jats:sup>\u00ae<\/jats:sup> system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The \u2018basic markers\u2019 were tested on 51 477 [fragrance mix <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">FM II<\/jats:styled-content>)] to 57 123 [<jats:italic>Myroxylon pereirae<\/jats:italic>, balsam of Peru] patients, and yielded positive reactions as follows: fragrance mix I 6.9%, <jats:italic>Myroxylon pereirae<\/jats:italic> 5.4%, <jats:styled-content style=\"fixed-case\">FM II<\/jats:styled-content> 3.8%, colophonium 2.6%, and hydroxyisohexyl 3\u2010cyclohexene carboxaldehyde 1.7%, with some regional differences. Prevalences with <jats:styled-content style=\"fixed-case\">TRUE T<\/jats:styled-content>est<jats:sup>\u00ae<\/jats:sup> allergens were lower. Additional fragrances were tested on 3643 (trimethylbenzenepropanol) to 14 071 (oil of turpentine) patients, and yielded between 2.6% (<jats:italic>Cananga odorata<\/jats:italic>) and 0.7% (trimethylbenzenepropanol) positive reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Contact allergy to fragrances is common throughout Europe, with regional variation probably being explained by patch test technique, and differences in exposure and referral patterns. The current basic markers of fragrance sensitivity in the baseline series should be supplemented with additional fragrance allergens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12420","type":"journal-article","created":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T08:24:53Z","timestamp":1434443093000},"page":"163-171","source":"Crossref","is-referenced-by-count":51,"title":["Patch test results with fragrance markers of the baseline series \u2013 analysis of the European Surveillance System on Contact Allergies (<scp>ESSCA<\/scp>) network 2009\u20132012"],"prefix":"10.1111","volume":"73","author":[{"given":"Peter J.","family":"Frosch","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Witten\/Herdecke  58448 Witten Germany"},{"name":"Department of Dermatology Klinikum Dortmund  44137 Dortmund Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Duus Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermato\u2010Allergology National Allergy Research Centre, Gentofte Hospital, University of Copenhagen  2900 Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Louise A.","family":"Schuttelaar","sequence":"additional","affiliation":[{"name":"Dermatology University Medical Centre Groningen, University of Groningen  9700 RB Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan F.","family":"Silvestre","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Alicante  03010 Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"S\u00e1nchez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario la Princesa  28006 Madrid 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