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The 2015 <jats:styled-content style=\"fixed-case\">EU L<\/jats:styled-content>eather <jats:styled-content style=\"fixed-case\">R<\/jats:styled-content>egulation once again put a focus on chromium allergy, emphasizing that the investigation of chromium allergy is still far from complete. Our review article on chromium focuses on the allergen's chemical properties, its potential exposure sources, and the allergen's interaction with the skin, and also provides an overview of the regulations, and analyses the epidemiological pattern between nations and across continents. 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