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As lettuce allergens and extracts are not commercially available, the allergy may be underdiagnosed. The aims of this article are to present new data on lettuce contact allergy and review the literature. Lettuce is weakly allergenic, and occupational cases are mainly reported. Using aimed patch testing in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ompositae\u2010allergic patients, two recent <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>anish studies showed prevalence rates of positive lettuce reactions of 11% and 22%. The majority of cases are non\u2010occupational, and may partly be caused by cross\u2010reactivity. The sesquiterpene lactone mix seems to be a poor screening agent for lettuce contact allergy, as the prevalence of positive reactions is significantly higher in non\u2010occupationally sensitized patients. Because of the easy degradability of lettuce allergens, it is recommended to patch test with freshly cut lettuce stem and supplement this with <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>ompositae mix. As contact urticaria and protein contact dermatitis may present as dermatitis, it is important to perform prick\u2013to\u2013prick tests, and possibly scratch patch tests as well. Any person who is occupationally exposed to lettuce for longer periods, especially atopics, amateur gardeners, and persons keeping lettuce\u2010eating pets, is potentially at risk of developing lettuce contact allergy.<\/jats:p>","DOI":"10.1111\/cod.12458","type":"journal-article","created":{"date-parts":[[2015,8,20]],"date-time":"2015-08-20T02:47:55Z","timestamp":1440038875000},"page":"67-75","source":"Crossref","is-referenced-by-count":36,"title":["Lettuce contact allergy"],"prefix":"10.1111","volume":"74","author":[{"given":"Evy","family":"Paulsen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark  DK\u20105000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, University of Southern Denmark  DK\u20105000 Odense C Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,19]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Allergiepflanzen\/Pflanzenallergene. 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