{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T23:08:23Z","timestamp":1773356903117,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004168","name":"University of L\u00fcbeck","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004168","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fruit\u2010derived organic compounds and detergents are relevant exposure factors for occupational contact dermatitis in the food industry. Although individuals with atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) are at risk for development of occupational contact dermatitis, there have been no controlled studies on the effects of repeated exposure to multiple irritants, relevant for the food industry, in atopic skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The aim of the study was to investigate the outcomes of repeated exposure to a fruit\u2010derived organic acid and a detergent in AD compared to healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The volunteers were exposed to 2.0% acetic acid (<jats:styled-content style=\"fixed-case\">AcA<\/jats:styled-content>) and\/or 0.5% sodium lauryl sulfate (<jats:styled-content style=\"fixed-case\">SLS<\/jats:styled-content>) in controlled tandem repeated irritation test. The outcomes were assessed by measurements of erythema, transepidermal water loss (<jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content>) and natural moisturizing factor (<jats:styled-content style=\"fixed-case\">NMF<\/jats:styled-content>) levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the  <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> volunteers, repeated <jats:styled-content style=\"fixed-case\">AcA<\/jats:styled-content> exposure led to barrier disruption and significant TEWL increase; no significant differences after the same exposure in the healthy controls were found. Repeated exposure to <jats:styled-content style=\"fixed-case\">SLS<\/jats:styled-content> and the irritant tandems enhanced the reactions and resulted in a significantly higher increase in <jats:styled-content style=\"fixed-case\">TEWL<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> compared to the control group. Cumulative irritant exposure reduced the  <jats:styled-content style=\"fixed-case\">NMF<\/jats:styled-content> levels in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Differences in the severity of irritant\u2010induced barrier impairment in atopic individuals contribute to the risk for occupational contact dermatitis in result of multiple exposures to food\u2010derived irritants and detergents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12464","type":"journal-article","created":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T22:32:24Z","timestamp":1443738744000},"page":"358-363","source":"Crossref","is-referenced-by-count":21,"title":["Barrier function and natural moisturizing factor levels after cumulative exposure to a fruit\u2010derived organic acid and a detergent: different outcomes in atopic and healthy skin and relevance for occupational contact dermatitis in the food industry"],"prefix":"10.1111","volume":"73","author":[{"given":"Irena","family":"Angelova\u2010Fischer","sequence":"first","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck  23538 L\u00fcbeck Germany"},{"name":"Comprehensive Center for Inflammation Medicine, University Hospital Schleswig\u2010Holstein  23538 L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Karin","family":"Hoek","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck  23538 L\u00fcbeck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Dapic","sequence":"additional","affiliation":[{"name":"Laboratory for Analytical Chemistry, Department of Chemistry and Biochemistry Faculty of Food Technology and Biotechnology, University of Zagreb  10000 Zagreb 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