{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:22:38Z","timestamp":1772223758048,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,8,28]],"date-time":"2015-08-28T00:00:00Z","timestamp":1440720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fragrance mix <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">FM<\/jats:styled-content> I) and its single constituents contain 5% and 1% sorbitan sesquioleate (<jats:styled-content style=\"fixed-case\">SSO<\/jats:styled-content>), respectively. <jats:styled-content style=\"fixed-case\">SSO<\/jats:styled-content> is a rare sensitizer and a potential irritant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine whether the outcome of the <jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content> breakdown test is affected by positive patch test reactivity to <jats:styled-content style=\"fixed-case\">SSO<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of data from the <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>nformation <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>etwork of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>epartments of <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content>ermatology, 1998\u20132013, was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The full <jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content> breakdown test including <jats:styled-content style=\"fixed-case\">SSO<\/jats:styled-content> was tested in 2952 patients. Of these, 154 (5.2%) had a positive patch test reaction to <jats:styled-content style=\"fixed-case\">SSO<\/jats:styled-content> 20% pet. and 2709 (91.8%) had a negative patch test reaction. Positive reactions to one or more of the single fragrances contained in the mix were significantly more common (82.5% versus 57.3%) in <jats:styled-content style=\"fixed-case\">SSO<\/jats:styled-content>\u2010positive patients, who also had more multiple reactions than <jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content>\u2010positive patients with negative <jats:styled-content style=\"fixed-case\">SSO<\/jats:styled-content> reactions (61.5% versus 21.3% patients with reactions to two or more fragrances).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that reactivity to <jats:styled-content style=\"fixed-case\">SSO<\/jats:styled-content> markedly affects the outcome of patch testing with <jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content> and its single constituents. <jats:styled-content style=\"fixed-case\">SSO<\/jats:styled-content> must be an obligatory part of the full <jats:styled-content style=\"fixed-case\">FM I<\/jats:styled-content> breakdown test, and should ideally be included in the baseline series.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12468","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T12:30:44Z","timestamp":1441197044000},"page":"296-304","source":"Crossref","is-referenced-by-count":23,"title":["Reactivity to sorbitan sesquioleate affects reactivity to fragrance mix I"],"prefix":"10.1111","volume":"73","author":[{"given":"Johannes","family":"Geier","sequence":"first","affiliation":[{"name":"Information Network of Departments of Dermatology Georg\u2010August University  37075 G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Axel","family":"Schnuch","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology Georg\u2010August University  37075 G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holger","family":"Lessmann","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology Georg\u2010August University  37075 G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Uter","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics, Biometry and Epidemiology University of Erlangen\/N\u00fcrnberg  91054 Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2011.10122"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12150"},{"key":"e_1_2_7_4_1","unstructured":"Baseline series of the German Contact Dermatitis Research Group (DKG). 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