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There is evidence that, in experimental animals, topical exposure to potent contact allergens is associated with <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content> cell activation and proliferation, and hapten\u2010specific antibody production. However, there is very limited evidence available for anti\u2010hapten antibody responses being induced following topical exposure of humans to contact allergens. Nevertheless, it is important to appreciate that there are almost no negative studies in which evidence for antibody production as the result of skin sensitization has been sought and not found. That is, there is absence of evidence rather than evidence of absence. Furthermore, exposure to chemical respiratory allergens, in which the skin has been implicated as a potential route of sensitization, results in anti\u2010hapten antibody responses. It is proposed that skin sensitization to contact allergens will normally be accompanied by antibody production. The phenomenon is worthy of investigation, as anti\u2010hapten antibodies could potentially influence and\/or regulate the induction of skin sensitization. Moreover, such antibodies may provide an informative correlate of the extent to which sensitization has been acquired.<\/jats:p>","DOI":"10.1111\/cod.12486","type":"journal-article","created":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T05:01:48Z","timestamp":1447304508000},"page":"197-204","source":"Crossref","is-referenced-by-count":18,"title":["Anti\u2010hapten antibodies in response to skin sensitization"],"prefix":"10.1111","volume":"74","author":[{"given":"Helen","family":"Singleton","sequence":"first","affiliation":[{"name":"Department of Toxicology, Faculty of Life Sciences University of Manchester  Manchester M13 9PT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Popple","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Faculty of Life Sciences University of Manchester  Manchester M13 9PT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nichola","family":"Gellatly","sequence":"additional","affiliation":[{"name":"Unilever Safety and Environmental Assurance Centre, Colworth Science Park  Bedford MK44 1LQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"Maxwell","sequence":"additional","affiliation":[{"name":"Unilever Safety and Environmental Assurance Centre, Colworth Science Park  Bedford MK44 1LQ UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Williams","sequence":"additional","affiliation":[{"name":"Salford Royal NHS Foundation Trust  Salford M6 8HD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter S.","family":"Friedmann","sequence":"additional","affiliation":[{"name":"Division of Infection, Inflammation &amp; 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