{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:03:46Z","timestamp":1773173026631,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T00:00:00Z","timestamp":1447372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Contact allergy in children is becoming increasingly recognized as a cause of eczema. The causal agents may change with time, but there are few comparative data for this age group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare data from the past 10 years with a similar study from the previous decade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2005 and 2014, 500 consecutive children who had been patch tested at Leeds Teaching Hospitals were identified, and the results were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven per cent (134 cases) of children had one or more positive patch test findings. The mean \u00b1 standard deviation age of patients with a positive test reaction was 11.9 \u00b1 4.1 years, which was significantly higher than that of patients with a negative result (10.9 \u00b1 4.0 years) (<jats:italic>p<\/jats:italic> = 0.01; Mann\u2013Whitney <jats:styled-content style=\"fixed-case\"><jats:italic>U<\/jats:italic><\/jats:styled-content>\u2010test). No significant relationship between sex and a positive patch test result was found (<jats:italic>p<\/jats:italic> = 0.48, chi\u2010squared). Allergy to nickel was the most frequent finding, although this accounted for 18%, rather than 33% (1995\u20132004), of all positive reactions. The next most common allergens included fragrance mix 1 (17%), <jats:italic>p<\/jats:italic>\u2010phenylenediamine (16%), and methylchloroisothiazolinone\/methylisothiazolinone (6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although the overall incidence of contact allergy in our paediatric population is static, there has been a significant change in the allergens detected, probably as a result of changes in European legislation and cosmetic product use in children.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12489","type":"journal-article","created":{"date-parts":[[2015,11,13]],"date-time":"2015-11-13T08:43:08Z","timestamp":1447404188000},"page":"37-43","source":"Crossref","is-referenced-by-count":51,"title":["Allergic contact dermatitis in children: trends in allergens, 10 years on. A retrospective study of 500 children tested between 2005 and 2014 in one <scp>UK<\/scp> centre"],"prefix":"10.1111","volume":"74","author":[{"given":"Vanessa M.","family":"Smith","sequence":"first","affiliation":[{"name":"Dermatology Department Chapel Allerton Hospital  Leeds LS7 4SA UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila M.","family":"Clark","sequence":"additional","affiliation":[{"name":"Dermatology Department Chapel Allerton Hospital  Leeds LS7 4SA UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Dermatology Department Chapel Allerton Hospital  Leeds LS7 4SA UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,13]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01963.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.2310\/6620.2008.07099","article-title":"Allergic contact dermatitis in children: the Ottawa hospital patch\u2010testing clinic experience, 1996 to 2006","volume":"19","author":"Hogeling 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