{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:08:45Z","timestamp":1791090525178,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T00:00:00Z","timestamp":1446681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2016,2]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Beside the basic resins, reactive diluents and hardeners are important sensitizers in epoxy resin systems (ERS<\/jats:styled-content>s). Because of chemical similarities, immunological cross\u2010reactivity may occur.<\/jats:p><\/jats:sec>Objectives<\/jats:title>To analyse concomitant reactivity among reactive diluents and hardeners in the patients concerned, as one integral part of a research project on the sensitizing capacity of ERS<\/jats:styled-content>s (FP<\/jats:styled-content>\u20100324).<\/jats:p><\/jats:sec>Methods<\/jats:title>A retrospective analysis of data from the I<\/jats:styled-content>nformation N<\/jats:styled-content>etwork of D<\/jats:styled-content>epartments of D<\/jats:styled-content>ermatology (IVDK<\/jats:styled-content>), 2002\u20132011, was performed.<\/jats:p><\/jats:sec>Results<\/jats:title>There was close concomitant reactivity to 1,6\u2010hexanediol diglycidyl ether and 1,4\u2010butanediol diglycidyl ether (1,4\u2010BDDGE<\/jats:styled-content>), and to phenyl glycidyl ether (PGE<\/jats:styled-content>) and cresyl glycidyl ether (CGE<\/jats:styled-content>), whereas reactions to p<\/jats:italic>\u2010tert\u2010butylphenyl glycidyl ether occurred more independently from those to PGE<\/jats:styled-content> and CGE<\/jats:styled-content>. Concomitant reactions to butyl glycidyl ether and 1,4\u2010BDDGE<\/jats:styled-content> may point to a common allergenic compound derived from the metabolism of 1,4\u2010BDDGE<\/jats:styled-content>. Among the structurally more diverse group of hardeners, there was no evidence of immunological cross\u2010reactions.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>More detailed knowledge of cross\u2010reactivity among ERS<\/jats:styled-content> components facilitates the interpretation of patch test results and will allow safer ERS<\/jats:styled-content>s to be composed in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.12490","type":"journal-article","created":{"date-parts":[[2015,11,5]],"date-time":"2015-11-05T09:24:46Z","timestamp":1446715486000},"page":"94-101","source":"Crossref","is-referenced-by-count":22,"title":["Sensitization to reactive diluents and hardeners in epoxy resin systems. IVDK<\/scp> data 2002\u20132011. Part II<\/scp>: concomitant reactions"],"prefix":"10.1111","volume":"74","author":[{"given":"Johannes","family":"Geier","sequence":"first","affiliation":[{"name":"Information Network of Departments of Dermatology University of G\u00f6ttingen 37075 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Lessmann","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology University of G\u00f6ttingen 37075 G\u00f6ttingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Hillen","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Essen 45122 Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Skudlik","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Environmental Medicine, and Health Theory University of Osnabr\u00fcck 49069 Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uta","family":"Jappe","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Heidelberg 69115 Heidelberg Germany"},{"name":"Department of Dermatology University of L\u00fcbeck 23538 L\u00fcbeck Germany"},{"name":"Division of Clinical and Molecular Allergology Research Centre Borstel, Airway Research Centre North, Member of the German Centre for Lung Research 23845 Borstel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,5]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","article-title":"Occupational skin diseases from epoxy compounds","volume":"71","author":"Jolanki R","year":"1991","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.44020920.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-07677-4_73"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-02035-3_51"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01634989-199106000-00004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12280"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12369"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12491"},{"key":"e_1_2_7_10_1","unstructured":"HeineK KalberlahF HassauerMet\u2009al.Ranking von Stoffen in Epoxidharzsystemen aufgrund ihrer sensibilisierenden Wirkst\u00e4rken (FP\u20100324). Final report on the research project FP\u20100324 published online in German language December2012. Available at:http:\/\/www.bgbau.de\/gisbau\/fachthemen\/epoxi\/downloads\/Gesamtbericht.pdf(last accessed 19 March 2015)."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2012.02834.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5414\/DBP53107"},{"key":"e_1_2_7_13_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.0105-1873.2004.00406.x","article-title":"Guidelines for the descriptive presentation and statistical analysis of contact allergy data","volume":"51","author":"Uter W","year":"2005","journal-title":"Contact Dermatitis"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2009.06787.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00465.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01475.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2004.20433"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00346.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-004-0575-5"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(94)90112-0"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx900193s"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.12490","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.12490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T04:06:31Z","timestamp":1696305991000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.12490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,5]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/cod.12490"],"URL":"https:\/\/doi.org\/10.1111\/cod.12490","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,5]]}}}